Fatty Acid Binding Protein 4, Adipocyte (FABP4) antibody

Details for Product No. ABIN659542
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Antigen
Synonyms FABP, AFABP, A-FABP, ALBP, AP2, FABP3, aP2, 422/aP2, ALBP/Ap2, Ap2, Lbpl, Albp, LOC100223994, fabp11, zgc:103587, FABP4, MGC84940, fabp4
Reactivity
Human
(137), (58), (45), (27), (24), (15), (3), (2)
Host
Mouse
(93), (49), (4), (2), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(7), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Western Blotting (WB)
(114), (73), (30), (20), (18), (13), (7), (6), (6), (6), (4), (2), (1)
Pubmed 2 references available
Catalog no. ABIN659542
Quantity 0.1 mg
Price
357.50 $   Plus shipping costs $45.00
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Immunogen Purified recombinant fragment of FABP4 expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of FABP4 expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name FABP4
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 14719 DA
Gene ID 12406
UniProt NP_001433.1, P15090
Research Area Phospho-specific antibodies, Cell Structure
Application Notes Western Bloting: = 1:500 - 2000.
Comment

Background: Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long chain fatty acids, their coenzymes and other hydrophobic ligands and small molecules in the cytoplasm. It is thought that the role of these proteins includes fatty acid uptake, intracellular lipid transport and metabolism. FABP4 encodes the fatty acid binding protein found in adipocytes. FABP4 knockout mice fed a high-fat and high-calorie diet become obese but develop neither insulin resistance nor diabetes, suggesting that this protein might be a link between obesity and insulin resistance and diabetes A related study in humans indicated a similar pattern, suggesting that FABP4 may be a potential therapeutic target in the treatment of these disorders.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Gericke, Smith, Moore et al.: "Adipocyte fatty acid-binding protein: interaction with phospholipid membranes and thermal stability studied by FTIR spectroscopy." in: Biochemistry, Vol. 36, Issue 27, pp. 8311-7, 1997 (PubMed).

Tuncman, Erbay, Hom et al.: "A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 18, pp. 6970-5, 2006 (PubMed).

Hosts (93), (49), (4), (2), (1)
Reactivities (137), (58), (45), (27), (24), (15), (3), (2)
Applications (114), (73), (30), (20), (18), (13), (7), (6), (6), (6), (4), (2), (1)
Conjugates (7), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Epitopes (18), (15), (6), (4), (4), (4), (4), (3), (3), (2), (2), (1), (1), (1)
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