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CTNNB1 antibody (Catenin (Cadherin-Associated Protein), beta 1, 88kDa)

Details for Product anti-CTNNB1 Antibody No. ABIN659545, Supplier: Login to see New
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(476), (118), (100), (28), (21), (16), (13), (6), (5), (4), (3), (2), (2), (1), (1), (1)
(341), (167), (2), (2)
This CTNNB1 antibody is un-conjugated
(15), (12), (9), (6), (6), (6), (1), (1), (1)
Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
(432), (159), (119), (111), (102), (71), (66), (39), (23), (13), (8), (4), (3), (3), (2), (1), (1), (1), (1)
Pubmed 3 references available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen Purified recombinant fragment of human CTNNB1 expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of human CTNNB1 expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CTNNB1 (CTNNB1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 85497 DA
Gene ID 12406
NCBI Accession NP_001895
UniProt P35222
Research Area Ubiquitin-related antibodies, Translation Factors, Phospho-specific antibodies, Cell Signaling, Transcription Factors, Signaling, Chromatin, Cell Structure
Pathways WNT Signaling
Application Notes Western Bloting: = 1:500 - 2000. Immunofluorescence: = 1:200 - 1000. Flow cytometry: = 1:200 - 400.

Background: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. The distinct peripheral cytosolic proteins, alpha, beta and gamma catenin (102, 94 and 86 kDa) are found in many tissues and bind to the conserved cytoplasmic tail domain of the cell adhesion cadherins. Catenins link E cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt1 proto oncogene. The central core region of beta catenin is involved in mediation of cadherin catenin complex interaction with EGFR. Beta-Catenin-mediated signalling is involved at several stages of vertebrate neural development.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Bougatef, Ouerhani, Moussa et al.: "Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer." in: Cancer genetics and cytogenetics, Vol. 187, Issue 1, pp. 12-8, 2008 (PubMed).

Guo, Liu, Yang et al.: "Relation among p130Cas, E-cadherin and beta-catenin expression, clinicopathologic significance and prognosis in human hepatocellular carcinoma." in: Hepatobiliary & pancreatic diseases international : HBPD INT, Vol. 7, Issue 5, pp. 490-6, 2008 (PubMed).

Rubinfeld, Souza, Albert et al.: "The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin." in: The Journal of biological chemistry, Vol. 270, Issue 10, pp. 5549-55, 1995 (PubMed).

Catalog No. ABIN659545

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