anti-BMP4 antibody (Bone Morphogenetic Protein 4)

Details for Product anti-BMP4 Antibody No. ABIN659548
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Antigen
Reactivity
Human
(143), (45), (43), (15), (13), (8), (8), (8), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Mouse
(163), (40), (8), (1)
Clonality
Monoclonal
Conjugate
This BMP4 antibody is un-conjugated
(19), (15), (5), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(148), (104), (55), (43), (28), (19), (11), (10), (5), (5), (3), (3), (1), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Immunogen Purified recombinant fragment of human BMP4 expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of human BMP4 expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BMP4 (BMP4 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 46555 DA
Gene ID 12406
NCBI Accession NP_570912
UniProt P12644
Research Area Cell Signaling, Cell Structure
Application Notes Western Bloting: = 1:500 - 2000.
Comment

Background: The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors.BMPs (bone morphogenetic proteins) belong to the TGF beta superfamily of structurally related signaling proteins. Members of this superfamily are widely represented throughout the animal kingdom and have been implicated in a variety of developmental processes. Proteins of the TGF beta superfamily are disulfide-linked dimers composed of two 12-15 kDa polypeptide chains. As implied by their name, BMPs initiate, promote and regulate bone development, growth, remodeling and repair. Smad1 translocation to the nucleus is observed after the addition of BMP4 (also designated BMP2B), suggesting that BMP4 may play a role in activation of the Smad pathway. BMP is secreted into the extracellular matrix.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Solmesky, Abekasis, Bulvik et al.: "Bone morphogenetic protein signaling is involved in human mesenchymal stem cell survival in serum-free medium." in: Stem cells and development, Vol. 18, Issue 9, pp. 1283-92, 2009 (PubMed).

Yerges, Klei, Cauley et al.: "High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 24, Issue 12, pp. 2039-49, 2009 (PubMed).

Oida, Iimura, Maruoka et al.: "Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library." in: DNA sequence : the journal of DNA sequencing and mapping, Vol. 5, Issue 5, pp. 273-5, 1995 (PubMed).

van den Wijngaard, Weghuis, Boersma et al.: "Fine mapping of the human bone morphogenetic protein-4 gene (BMP4) to chromosome 14q22-q23 by in situ hybridization." in: Genomics, Vol. 27, Issue 3, pp. 559-60, 1995 (PubMed).

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Catalog No. ABIN659548
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