|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Bone Morphogenetic Protein 4 (BMP4) antibody
|Synonyms||ZYME, BMP2B, OFC11, BMP2B1, MCOPS6, Bmp-4, Bmp2b, Bmp2b1, Bmp2b-1, BOMPR4A, bmp-4, zbmp-4, MGC100779, zgc:100779, BMP4, BMP-4, xbmp4, XBMP-4, Bmp4, MGC127497, zyme, bmp2b, bmp2b1, bmp4|
Alternatives Western Blotting (WB), ELISA
|4 references available|
|Price||357.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||Purified recombinant fragment of human BMP4 expressed in E. Coli.|
|Description||Other names: ZYME, BMP2B, OFC11, BMP2B1, MCOPS6, BMP4|
|Characteristics||Mouse Monoclonal Antibody to BMP4|
|Specificity||Purified recombinant fragment of human BMP4 expressed in E. Coli.|
|Molecular Weight||46555 DA|
Background: The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors.BMPs (bone morphogenetic proteins) belong to the TGF beta superfamily of structurally related signaling proteins. Members of this superfamily are widely represented throughout the animal kingdom and have been implicated in a variety of developmental processes. Proteins of the TGF beta superfamily are disulfide-linked dimers composed of two 12-15 kDa polypeptide chains. As implied by their name, BMPs initiate, promote and regulate bone development, growth, remodeling and repair. Smad1 translocation to the nucleus is observed after the addition of BMP4 (also designated BMP2B), suggesting that BMP4 may play a role in activation of the Smad pathway. BMP is secreted into the extracellular matrix.
|Application Notes||The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000.|
|Buffer||Purified recombinant fragment of human BMP4 expressed in E. Coli.|
|Storage||BMP4 Antibody can be stored at 4?, for long term storage, store at -20?.|
|Research Area||Cell Signaling, Cell Structure|
|Restrictions||For Research Use only|
van den Wijngaard, Weghuis, Boersma et al.: "Fine mapping of the human bone morphogenetic protein-4 gene (BMP4) to chromosome 14q22-q23 by in situ hybridization." in: Genomics, Vol. 27, Issue 3, pp. 559-60, 1995 (PubMed).
Oida, Iimura, Maruoka et al.: "Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library." in: DNA sequence : the journal of DNA sequencing and mapping, Vol. 5, Issue 5, pp. 273-5, 1995 (PubMed).
Yerges, Klei, Cauley et al.: "High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 24, Issue 12, pp. 2039-49, 2009 (PubMed).
Solmesky, Abekasis, Bulvik et al.: "Bone morphogenetic protein signaling is involved in human mesenchymal stem cell survival in serum-free medium." in: Stem cells and development, Vol. 18, Issue 9, pp. 1283-92, 2009 (PubMed).