|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Nerve Growth Factor Receptor (NGFR) antibody
|Synonyms||CD271, p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, MGC148470, NGFR, wu:fb38c02, wu:fc10h01, p75, LNGFR, RNNGFRR, nrh1, NRH1b, p75ntr, tnfrsf16, MGC131034|
Alternatives Western Blotting (WB), Flow Cytometry (FACS), Immunocytochemistry (ICC), ELISA
|4 references available|
|Price||357.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||Purified recombinant fragment of human NGFR expressed in E. Coli.|
|Description||Other names: CD271, p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, NGFR|
|Characteristics||Mouse Monoclonal Antibody to NGFR|
|Specificity||Purified recombinant fragment of human NGFR expressed in E. Coli.|
|Molecular Weight||45183 DA|
Background: Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGFR p75 plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of NGFR p75 by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE like proteases and the JNK pathway. In rat Schwann cells, NGF binding to NGFR p75 activates NF kappaB, possibly to modulate Schwann cell migration during nerve regeneration. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells).
|Application Notes||The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000. Immunofluorescence: ~~ 1:200 - 1000. Flow cytometry: ~~ 1:200 - 400.|
|Buffer||Purified recombinant fragment of human NGFR expressed in E. Coli.|
|Storage||NGFR Antibody can be stored at 4?, for long term storage, store at -20?.|
|Research Area||Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Cell Structure, Neurology|
|Restrictions||For Research Use only|
Fantini, Johansson: "Expression of growth-associated protein 43 and nerve growth factor receptor in human skin: a comparative immunohistochemical investigation." in: The Journal of investigative dermatology, Vol. 99, Issue 6, pp. 734-42, 1993 (PubMed).
DiDonato, Hayakawa, Rothwarf et al.: "A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB." in: Nature, Vol. 388, Issue 6642, pp. 548-54, 1997 (PubMed).
Hu, Zhang, Qin et al.: "Increased p75(NTR) expression in hippocampal neurons containing hyperphosphorylated tau in Alzheimer patients." in: Experimental neurology, Vol. 178, Issue 1, pp. 104-11, 2002 (PubMed).
He, Garcia: "Structure of nerve growth factor complexed with the shared neurotrophin receptor p75." in: Science (New York, N.Y.), Vol. 304, Issue 5672, pp. 870-5, 2004 (PubMed).