Keratin 7 (KRT7) antibody

Details for Product No. ABIN659567
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Antigen
Reactivity
Human
(265), (64), (47), (7), (5), (5), (5), (5), (3), (2), (1), (1), (1)
Host
Mouse
(156), (141), (3)
Clonality
Monoclonal
Conjugate
Un-conjugated
(18), (11), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Flow Cytometry (FACS), Western Blotting (WB)
(211), (105), (99), (72), (55), (44), (42), (41), (20), (14), (13), (10), (6), (3), (2), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Immunogen Purified recombinant fragment of human CK7 expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of human CK7 expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CK7 (KRT7 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 51405 DA
Gene ID 12406
NCBI Accession NP_005547
UniProt P08729
Research Area Signaling, Phospho-specific antibodies, Cell Structure
Application Notes The suggested dilution is: Western Bloting: = 1:500 - 2000. Flow cytometry: = 1:200 - 400.
Comment

Background: CK7 (Keratin, type II cytoskeletal 7) is a protein that in humans is encoded by the KRT7 gene. CK7 is a member of the keratin family. It is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants, however, not all variants have been fully described.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Schweizer, Bowden, Coulombe et al.: "New consensus nomenclature for mammalian keratins." in: The Journal of cell biology, Vol. 174, Issue 2, pp. 169-74, 2006 (PubMed).

Bouwens: "Cytokeratins and cell differentiation in the pancreas." in: The Journal of pathology, Vol. 184, Issue 3, pp. 234-9, 1998 (PubMed).

Rosenberg, Fuchs, Le Beau et al.: "Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12." in: Cytogenetics and cell genetics, Vol. 57, Issue 1, pp. 33-8, 1991 (PubMed).

Validation Images
Catalog No. ABIN659567
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