Intercellular Adhesion Molecule 1 (ICAM1) antibody

Details for Product No. ABIN659584
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Antigen
Synonyms BB2, CD54, P3.58, Icam-1, Ly-47, MALA-2, ICAM, ICAM-1, ICAM1
Reactivity
Human
(467), (124), (69), (8), (2), (1)
Host
Mouse
(306), (215), (71), (6), (4), (3)
Clonality
Monoclonal
Conjugate
Un-conjugated
(56), (54), (50), (9), (7), (7), (6), (5), (5), (5), (5), (5), (5), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(336), (233), (136), (108), (101), (99), (64), (50), (39), (38), (31), (16), (16), (12), (6), (5), (4), (3), (3), (2), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN659584
357.50 $
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Immunogen Purified recombinant fragment of human ICAM1(28-480aa) expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of human ICAM1(28-480aa) expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ICAM1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 57825 DA
Gene ID 12406
NCBI Accession NP_000192
UniProt P05362
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Cell Structure
Application Notes Western Bloting: = 1:500 - 2000.
Comment

Background: ICAM1 is a 85-110 kDa single chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. It shares considerable amino acid sequence homology with ICAM3 and with ICAM2. ICAM1 is expressed by activated endothelial cells. It is detected on cells of many other lineages (e.g. epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils), with lower levels that increase in inflammation. ICAM1 is also detected in some carcinoma and melanoma cells. Soluble ICAM1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes. It is the receptor for rhinoviruses and malaria.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Rössler, Neuchrist, Kitz et al.: "Expression of leucocyte adhesion molecules at the human blood-brain barrier (BBB)." in: Journal of neuroscience research, Vol. 31, Issue 2, pp. 365-74, 1992 (PubMed).

Barreiro, Yanez-Mo, Serrador et al.: "Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes." in: The Journal of cell biology, Vol. 157, Issue 7, pp. 1233-45, 2002 (PubMed).

Yang, Cullen, Li et al.: "Susceptibility to primary sclerosing cholangitis is associated with polymorphisms of intercellular adhesion molecule-1." in: Journal of hepatology, Vol. 40, Issue 3, pp. 375-9, 2004 (PubMed).

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