Snail Homolog 2 (Drosophila) (SNAI2) antibody

Details for Product No. ABIN659591
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Antigen
Reactivity
Human
(110), (41), (28), (1), (1), (1), (1), (1)
Host
Mouse
(68), (42)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(87), (36), (20), (16), (14), (10), (9), (4), (2), (2), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Immunogen Purified recombinant fragment of human SNAI2 expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of human SNAI2 expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SNAI2 (SNAI2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 29986 DA
Gene ID 12406
NCBI Accession NP_003059
UniProt O43623
Research Area Translation Factors, Transcription Factors, Cell Structure
Application Notes Western Bloting: = 1:500 - 2000.
Comment

Background: This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.The tumor suppressor protein p53 induces Slug expression in ?-irradiated cells, Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Mutations in this gene may be associated with sporatic cases of neural tube defects.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Saegusa, Hashimura, Kuwata et al.: "Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug." in: The American journal of pathology, Vol. 174, Issue 6, pp. 2107-15, 2009 (PubMed).

Medici, Hay, Olsen: "Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3." in: Molecular biology of the cell, Vol. 19, Issue 11, pp. 4875-87, 2008 (PubMed).

Ye, Xiao, Wang et al.: "ERalpha suppresses slug expression directly by transcriptional repression." in: The Biochemical journal, Vol. 416, Issue 2, pp. 179-87, 2008 (PubMed).

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Catalog No. ABIN659591
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