Snail Homolog 2 (Drosophila) (SNAI2) antibody

Details for Product No. ABIN659591
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Antigen
Synonyms SLUG, SLUGH1, SNAIL2, WS2D, Slug, Slugh, Snail2, slug, cb147, cb355, sb:cb355, sb:cb569, zgc:92564, id:ibd5003, wu:fb83e12, wu:fd19g11, XSnail2, snai2, xslug, xsna, ws2d, xSlu, slugh1
Reactivity
Human
(108), (55), (40), (14), (14), (13), (13), (1), (1)
Host
Mouse
(68), (39)
Clonality
Monoclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application
Western Blotting (WB)
(80), (41), (22), (20), (17), (12), (7), (3), (3), (2), (2), (1)
Pubmed 3 references available
Catalog no. ABIN659591
Quantity 0.1 mg
Price
357.50 $   Plus shipping costs $45.00
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Immunogen Purified recombinant fragment of human SNAI2 expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of human SNAI2 expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SNAI2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 29986 DA
Gene ID 12406
UniProt O43623, NP_003059.1
Research Area Translation Factors, Transcription Factors, Cell Structure
Application Notes Western Bloting: = 1:500 - 2000.
Comment

Background: This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.The tumor suppressor protein p53 induces Slug expression in ?-irradiated cells, Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Mutations in this gene may be associated with sporatic cases of neural tube defects.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Ye, Xiao, Wang et al.: "ERalpha suppresses slug expression directly by transcriptional repression." in: The Biochemical journal, Vol. 416, Issue 2, pp. 179-87, 2008 (PubMed).

Medici, Hay, Olsen: "Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3." in: Molecular biology of the cell, Vol. 19, Issue 11, pp. 4875-87, 2008 (PubMed).

Saegusa, Hashimura, Kuwata et al.: "Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug." in: The American journal of pathology, Vol. 174, Issue 6, pp. 2107-15, 2009 (PubMed).

Hosts (68), (39)
Reactivities (108), (55), (40), (14), (14), (13), (13), (1), (1)
Applications (80), (41), (22), (20), (17), (12), (7), (3), (3), (2), (2), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Epitopes (13), (13), (13), (13), (13), (9), (6), (5), (3), (3), (3), (3), (2), (1), (1), (1), (1)
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