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Janus Kinase 2 (JAK2) antibody

Antigen

Janus Kinase 2 (JAK2)
Synonyms JTK10, Fd17, C81284, AI504024, JAK2, DKFZp469G074
Clonality Monoclonal
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), ELISA
3 references available
Certificates ISO 9001:2008
Catalog no. ABIN659595
Quantity 0.1ml
Price 357.50 $   Plus shipping costs $45.00
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Additional Information
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Alternative name JAK2
Gene ID 3717
UniProt O60674, NP_004963.1
Immunogen Purified recombinant fragment of JAK2(745-955aa) expressed in E. Coli.
Isotype IgG1
Description Other names: JTK10, JAK2
Characteristics Mouse Monoclonal Antibody to JAK2
Specificity Purified recombinant fragment of JAK2(745-955aa) expressed in E. Coli.
Molecular Weight 130674 DA
Comments

Background: This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.

Application Details
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Application Notes The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000.
Buffer Purified recombinant fragment of JAK2(745-955aa) expressed in E. Coli.
Storage JAK2 Antibody can be stored at 4?, for long term storage, store at -20?.
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Cell Structure, Signaling, Chromatin
Restrictions For Research Use only

Publications
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Product Pezet, Buteau, Kelly et al.: "The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor." in: Molecular and cellular endocrinology, Vol. 129, Issue 2, pp. 199-208, 1997 (PubMed).

Pollack, Kotenko, He et al.: "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity." in: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31531-42, 1999 (PubMed).

Hermanns, Radtke, Haan et al.: "Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 12, pp. 6651-8, 2000 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Janus Kinase 2 (JAK2)", type "Antibodies"
Hosts Rabbit (86), Mouse (5), Goat (1)
Reactivities Human (82), Rat (Rattus) (65), Mouse (Murine) (57), Chicken (28), Pig (Porcine) (28), Cow (Bovine) (18), Dog (Canine) (18), Zebrafish (10)
Applications Western Blotting (WB) (42), Immunohistochemistry (IHC) (35), ELISA (32), Immunofluorescence (IF) (28), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (9), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (2), Immunocytochemistry (ICC) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Biotin (4), Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), PE,Cy5.5 (3), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes pTyr1007 (9), pTyr221 (8), pTyr1008,pTyr1007 (4), C-Term (3), AA 745-955 (2), Tyr1007 (2), pTyr211 (2), Center (1), pTyr1007, pTyr1008 (1), pTyr372 (1), pTyr570 (1), pTyr654,pTyr653 (1), pTyr931 (1), pTyr972 (1)