anti-Jak2 antibody (Janus Kinase 2)

Details for Product anti-JAK2 Antibody No. ABIN659595
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Antigen
Reactivity
Human
(244), (166), (162), (1), (1), (1), (1), (1), (1)
Host
Mouse
(245), (10), (4)
Clonality
Monoclonal
Conjugate
This Jak2 antibody is un-conjugated
(10), (6), (6), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1)
Application
Western Blotting (WB)
(172), (117), (115), (34), (30), (23), (14), (9), (9), (6), (3), (3), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Immunogen Purified recombinant fragment of JAK2(745-955aa) expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of JAK2(745-955aa) expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name JAK2 (JAK2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 130674 DA
Gene ID 12406
NCBI Accession NP_004963
UniProt O60674
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Cell Structure, Signaling, Chromatin
Application Notes Western Bloting: = 1:500 - 2000.
Comment

Background: This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Hermanns, Radtke, Haan et al.: "Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 12, pp. 6651-8, 2000 (PubMed).

Pollack, Kotenko, He et al.: "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity." in: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31531-42, 1999 (PubMed).

Pezet, Buteau, Kelly et al.: "The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor." in: Molecular and cellular endocrinology, Vol. 129, Issue 2, pp. 199-208, 1997 (PubMed).

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Catalog No. ABIN659595
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