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BMX Non-Receptor Tyrosine Kinase (BMX) antibody

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(146), (91), (51), (6), (2), (2), (1), (1), (1), (1)
(135), (14)
(5), (5), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2)
Western Blotting (WB)
(107), (58), (56), (36), (34), (21), (10), (7), (3), (2)
Pubmed 4 references available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen Purified recombinant fragment of human BMX expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of human BMX expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BMX (BMX Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 78011 DA
Gene ID 12406
NCBI Accession NP_975010
UniProt P51813
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Signaling, Chromatin, Cell Structure
Application Notes Western Bloting: = 1:500 - 2000.

Background: BMX (bone marrow X kinase) is a cytoplasmic tyrosine kinase identified by reverse transcription of mRNA isolated from human bone marrow and mapped to the chromosomal band Xp22.2. The full length protein is 675 amino acids with a tyrosine kinase domain, an amino terminal pleckstrin domain, as well as an SH3 and SH2 domain. Direct comparison of BMX's primary sequence with other kinases showed that this is highly related to the family of BTK/ITK/TEC. BMX kinase is expressed in fetal and adult tissues, with the highest expression in heart, testis, small intestine and colon. It is undetectable in spleen, brain, kidney, and pancreas. Further analysis of mRNA expression showed that BMX is expressed in hematopoietic tissues and neutrophilic granulocytes, and in patients with acute and myeloid leukemia. The levels of BMX mRNA were substantially lower in patients with acute and chronic lymphoid leukemias, thus suggesting that BMX may be important during myelopoiesis.CST:It is expressed in a variety of hematopoietic, epithelial and endothelial cells.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Product cited in: Chakrabarti, Davidge: "Estradiol modulates tumor necrosis factor-induced endothelial inflammation: role of tumor necrosis factor receptor 2." in: Journal of vascular research, Vol. 50, Issue 1, pp. 21-34, 2012 (PubMed).

Background publications Palmer, Mutch, Workman et al.: "Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkapp}B activity." in: Blood, Vol. 111, Issue 4, pp. 1781-8, 2008 (PubMed).

Côté, Motoyama, Bush et al.: "A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling." in: Nature cell biology, Vol. 7, Issue 8, pp. 797-807, 2005 (PubMed).

Kim, Jiang, Xie et al.: "Synergism of cytoplasmic kinases in IL6-induced ligand-independent activation of androgen receptor in prostate cancer cells." in: Oncogene, Vol. 23, Issue 10, pp. 1838-44, 2004 (PubMed).

Catalog No. ABIN659597

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