|+1 404 474 4654|
|+1 888 205 9894 (TF)|
BMX Non-Receptor Tyrosine Kinase (BMX) antibody
|Synonyms||ETK, PSCTK2, PSCTK3, Etk, Tyro8, Etk/Bmx, RGD1565643, BMX|
Alternatives Western Blotting (WB), ELISA
|4 references available|
|Price||357.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||Purified recombinant fragment of human BMX expressed in E. Coli.|
|Description||Other names: ETK, PSCTK2, PSCTK3, BMX|
|Characteristics||Mouse Monoclonal Antibody to BMX|
|Specificity||Purified recombinant fragment of human BMX expressed in E. Coli.|
|Molecular Weight||78011 DA|
Background: BMX (bone marrow X kinase) is a cytoplasmic tyrosine kinase identified by reverse transcription of mRNA isolated from human bone marrow and mapped to the chromosomal band Xp22.2. The full length protein is 675 amino acids with a tyrosine kinase domain, an amino terminal pleckstrin domain, as well as an SH3 and SH2 domain. Direct comparison of BMX's primary sequence with other kinases showed that this is highly related to the family of BTK/ITK/TEC. BMX kinase is expressed in fetal and adult tissues, with the highest expression in heart, testis, small intestine and colon. It is undetectable in spleen, brain, kidney, and pancreas. Further analysis of mRNA expression showed that BMX is expressed in hematopoietic tissues and neutrophilic granulocytes, and in patients with acute and myeloid leukemia. The levels of BMX mRNA were substantially lower in patients with acute and chronic lymphoid leukemias, thus suggesting that BMX may be important during myelopoiesis.CST:It is expressed in a variety of hematopoietic, epithelial and endothelial cells.
|Application Notes||The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000.|
|Buffer||Purified recombinant fragment of human BMX expressed in E. Coli.|
|Storage||BMX Antibody can be stored at 4?, for long term storage, store at -20?.|
|Research Area||Ubiquitin-related antibodies, Phospho-specific antibodies, Signaling, Chromatin, Cell Structure|
|Restrictions||For Research Use only|
Kim, Jiang, Xie et al.: "Synergism of cytoplasmic kinases in IL6-induced ligand-independent activation of androgen receptor in prostate cancer cells." in: Oncogene, Vol. 23, Issue 10, pp. 1838-44, 2004 (PubMed).
C�té, Motoyama, Bush et al.: "A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling." in: Nature cell biology, Vol. 7, Issue 8, pp. 797-807, 2005 (PubMed).
Palmer, Mutch, Workman et al.: "Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkapp}B activity." in: Blood, Vol. 111, Issue 4, pp. 1781-8, 2008 (PubMed).
Chakrabarti, Davidge: "Estradiol modulates tumor necrosis factor-induced endothelial inflammation: role of tumor necrosis factor receptor 2." in: Journal of vascular research, Vol. 50, Issue 1, pp. 21-34, 2012 (PubMed).
|Hosts||Rabbit (81), Mouse (4)|
|Reactivities||Human (85), Mouse (Murine) (70), Rat (Rattus) (59), Cow (Bovine) (54), Dog (Canine) (54), Horse (Equine) (54), Pig (Porcine) (54)|
|Applications||Immunofluorescence (IF) (55), Western Blotting (WB) (39), ELISA (27), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (18), Immunohistochemistry (IHC) (11), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (9), Immunoprecipitation (IP) (5), Immunoelectron Microscopy (IEM) (3), Immunocytochemistry (ICC) (2)|
|Conjugates||Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), Biotin (3), Cy3 (3), Cy5 (3), Cy5.5 (3), Cy7 (3), FITC (3), Gold (3), HRP (3), PE (3), PE,Cy3 (3), PE,Cy5 (3), PE,Cy5.5 (3), PE,Cy7 (3)|
|Epitopes||pTyr40 (20), pTyr556 (18), N-Term (3), C-Term (1), Center (1), Cytoplasmic,C-Term (1), Cytoplasmic,C-Term,pTyr566 (1), Internal Region (1), pTyr566 (1)|