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Oncostatin M Protein (OSM) (AA 26-234) (His tag)

OSM Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS - PAGE SDS
Catalog No. ABIN667495
  • Target See all Oncostatin M (OSM) Proteins
    Oncostatin M (OSM)
    Protein Type
    Recombinant
    Protein Characteristics
    AA 26-234
    Origin
    • 24
    • 7
    • 4
    • 3
    • 1
    • 1
    Human
    Source
    • 20
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This Oncostatin M protein is labelled with His tag.
    Application
    SDS-PAGE (SDS)
    Characteristics
    OSM, 26-234aa, Human, His tag, E.coli
    Purity
    > 95 % by SDS - PAGE
    Top Product
    Discover our top product OSM Protein
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/ml (determined by Bradford assay)
    Buffer
    Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 1mM DTT
    Storage
    4 °C
  • Target
    Oncostatin M (OSM)
    Alternative Name
    OSM (OSM Products)
    Synonyms
    OSM Protein, OncoM Protein, oncostatin M Protein, OSM Protein, Osm Protein
    Background
    OSM, also known as Oncostatin M, is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. However, it is as yet poorly defined and is proving important in liver development, haematopoeisis, inflammation and possibly CNS development. It is also associated with bone formation and destruction. OSM signals through cell surface receptors that contain the protein gp130. The type I receptor is composed of gp130 and LIFR, the type II receptor is composed of gp130 and OSMR. Recombinant human OSM protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: Oncostatin M, MGC20461, Oncostatin M precursor. NCBI no.: NP_065391
    Molecular Weight
    25.9 kDa (230aa), confirmed by MALDI-TOF
    Pathways
    JAK-STAT Signaling, Negative Regulation of Hormone Secretion
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