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+1 404 474 4654 |
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+1 888 205 9894 (TF) |
Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) antibody (RBITC)
| Antigen | Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) |
| Synonyms | CLG, CLGN, Dm1-MMP, l(2)k04809, mmp1, DmelCG4859, CG4859, MMP1, Mmp1a, Mmp1 |
| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Mouse (Murine), Rat (Rattus) |
| Conjugate |
Alternatives RBITC |
| Application |
Alternatives Flow Cytometry (FACS), Immunofluorescence (IF)
|
| Catalog no. | ABIN668945 |
| Quantity | 100 µg (Variants) |
| Price | 290.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 10 to 15 Business Days |
Additional Information
| Alternative name | MMP-1 |
| Immunogen | Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human MMP1 C-terminus |
| Format | Lyophilized |
| Reconstitution | Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%) |
| Description | Synonym: CLGN, CLG, Fibroblast collagenase, Interstitial collagenase, Matrix metallopeptidase 1 (interstitial collagenase), Matrix Metalloproteinase 1, MMP 1. |
| Specificity | Excitation / Emission Wavelengths: 495nm/519nm |
| Comments |
The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively these enzymes can degrade all the components of the extracellular matrix including fibrillar and non fibrillar collagens fibronectin laminin and basement membrane glycoproteins. In general a signal peptide a propeptide and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition fibronectin like repeats a hinge region and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase gelatinase stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes and most of them are secreted from the cells as proenzymes. Thus the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing apoptosis bone elongation embryo development uterine involution angiogenesis and tissue remodeling and in diseases such as multiple sclerosis Alzheimer's malignant gliomas lupus arthritis periodontis glumerulonephritis atherosclerosis tissue ulceration and in cancer cell invasion and metastasis. |
Application Details
| Application Notes | Flow-Cyt(1:50-200), IF(1:50-200) |
| Purification | Antibodies are purified by protein A and peptide affinity chromatography. |
| Buffer | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
| Storage | Ship at room temperature. Store at -20°C |
| Research Area | Extracellular Matrix |
| Restrictions | For Research Use only |
