MME antibody (Membrane Metallo-Endopeptidase) (AA 500-550)

Details for Product anti-MME Antibody No. ABIN669666, Supplier: Log in to see
Antigen
  • CALLA
  • CD10
  • NEP
  • SFE
  • 6030454K05Rik
  • C85356
  • Nep
  • neprilysin
  • membrane metalloendopeptidase
  • membrane metallo endopeptidase
  • membrane metallo-endopeptidase
  • MME
  • Mme
Alternatives
anti-Human MME antibody for Immunoprecipitation
Epitope
AA 500-550
37
36
23
15
15
14
13
12
10
8
8
6
6
5
5
5
4
4
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
623
98
82
16
14
4
3
2
2
2
2
2
1
1
1
1
Host
Rabbit
439
197
4
3
Clonality
Polyclonal
Conjugate
This MME antibody is un-conjugated
61
48
43
28
11
10
10
10
9
8
6
6
6
6
6
5
5
5
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
315
308
214
180
128
85
83
50
49
21
12
10
5
4
4
2
2
2
1
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen KLH conjugated synthetic peptide derived from human CD10
Isotype IgG
Purification Purified by Protein A.
Alternative Name CD10 (MME Antibody Abstract)
Background

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 3 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.

Subcellular location: Extracellular

Synonyms: NEP, SFE, CD1, CALLA, Neprilysin, Atriopeptidase, Common acute lymphocytic leukemia antigen, Enkephalinase, Neutral endopeptidase 24.11, Neutral endopeptidase, Skin fibroblast elastase, MME, EPN

Gene ID 4311
UniProt P08473
Research Area Cancer, Hematopoietic Progenitors, Hematopoietic Stem Cells, CD Antigens, Adaptive Immunity, Surface Receptors of Immune Cells
Pathways RTK Signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration
Application Notes WB 1:100-1000
FCM 1:20-100
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Membrane Metallo-Endopeptidase (MME) (AA 500-550) antibody (ABIN669666) Formalin-fixed and paraffin embedded mouse small intestine tissue labeled with Anti-C...
Immunofluorescence (IF) image for anti-Membrane Metallo-Endopeptidase (MME) (AA 500-550) antibody (ABIN669666) Formalin-fixed and paraffin embedded mouse small intestine tissue labeled with Anti-C...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Membrane Metallo-Endopeptidase (MME) (AA 500-550) antibody (ABIN669666) Paraformaldehyde-fixed, paraffin embedded human colon carcinoma, Antigen retrieval by...
Flow Cytometry (FACS) image for anti-Membrane Metallo-Endopeptidase (MME) (AA 500-550) antibody (ABIN669666) A549 cells probed with CD10 Polyclonal Antibody, Unconjugated at 1:20 for 30 minutes...
Flow Cytometry (FACS) image for anti-Membrane Metallo-Endopeptidase (MME) (AA 500-550) antibody (ABIN669666) Human Hela cells probed with CD10 Polyclonal Antibody, Alexa Fluor 647 conjugated -A6...
Product cited in: Chopra, Kraus, Schwinn, Ritz, Mattenheimer, Mottok, Rosenwald, Einsele, Beilhack: "Non-invasive bioluminescence imaging to monitor the immunological control of a plasmablastic lymphoma-like B cell neoplasia after hematopoietic cell transplantation." in: PLoS ONE, Vol. 8, Issue 12, pp. e81320, 2013 (PubMed).

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