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CDK6 antibody (AA 21-110)

CDK6 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), FACS Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN670236
  • Target See all CDK6 Antibodies
    CDK6 (Cyclin-Dependent Kinase 6 (CDK6))
    Binding Specificity
    • 22
    • 21
    • 14
    • 11
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 21-110
    Reactivity
    • 126
    • 47
    • 24
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    Human, Mouse, Rat
    Host
    • 109
    • 17
    Rabbit
    Clonality
    • 98
    • 28
    Polyclonal
    Conjugate
    • 67
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This CDK6 antibody is un-conjugated
    Application
    • 75
    • 37
    • 29
    • 26
    • 26
    • 24
    • 22
    • 13
    • 7
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)
    Cross-Reactivity
    Human, Mouse, Rat
    Predicted Reactivity
    Dog,Cow,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CDK6
    Isotype
    IgG
    Top Product
    Discover our top product CDK6 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • He, Zheng, Zhang, Gan, Zhou, Liang, Wu, Ge, Deng, Xu: "Long non-coding RNA AK058003, as a precursor of miR-15a, interacts with HuR to inhibit the expression of γ-synuclein in hepatocellular carcinoma cells." in: Oncotarget, Vol. 8, Issue 6, pp. 9451-9465, (2016) (PubMed).

    Yang, Wang, Hui, Li, Jiang: "SOX 1, contrary to SOX 2, suppresses proliferation, migration, and invasion in human laryngeal squamous cell carcinoma by inhibiting the Wnt/?-catenin pathway." in: Tumour biology, (2015) (PubMed).

    Hu, Fan, Lv, Zhou, Yang, Zheng, Cao: "5-Aminolevulinic acid-mediated sonodynamic therapy induces anti-tumor effects in malignant melanoma via p53-miR-34a-Sirt1 axis." in: Journal of dermatological science, Vol. 79, Issue 2, pp. 155-62, (2015) (PubMed).

    Zhang, Wang, Li, Huo, Mu, Liu, Han: "miR-145 downregulates the expression of cyclin-dependent kinase 6 in human cervical carcinoma cells." in: Experimental and therapeutic medicine, Vol. 8, Issue 2, pp. 591-594, (2014) (PubMed).

    Zhang, Zhu, Zuo, Luo, Mao, Ye, Li, Liu, Wei, Ye, Chen, Wang: "The ClC-3 chloride channel protein is a downstream target of cyclin D1 in nasopharyngeal carcinoma cells." in: The international journal of biochemistry & cell biology, Vol. 45, Issue 3, pp. 672-83, (2013) (PubMed).

  • Target
    CDK6 (Cyclin-Dependent Kinase 6 (CDK6))
    Alternative Name
    CDK6 (CDK6 Products)
    Synonyms
    CDK6 antibody, PLSTIRE antibody, 5830411I20 antibody, AI504062 antibody, Crk2 antibody, cyclin dependent kinase 6 antibody, cyclin-dependent kinase 6 antibody, CDK6 antibody, Cdk6 antibody
    Background

    Synonyms: MCPH12, PLSTIRE, Cyclin-dependent kinase 6, Cell division protein kinase 6, Serine/threonine-protein kinase PLSTIRE, CDK6, CDKN6

    Background: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation, promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation, prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).

    Gene ID
    1021
    UniProt
    Q00534
    Pathways
    Cell Division Cycle, Mitotic G1-G1/S Phases
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