Endoglin antibody (AA 601-658)

Catalog No. ABIN670401

Product Details anti-Endoglin Antibody

Target: Endoglin (ENG)

Binding Specificity: AA 601-658

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Endoglin antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CD105

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-Endoglin antibody (ABIN670401)

Hussien, Ebrahim, Mohammed, Sabry: "Combination of Obestatin and Bone Marrow Mesenchymal Stem Cells Prevents Aggravation of Endocrine Pancreatic Damage in Type II Diabetic Rats." in: International journal of stem cells, Vol. 10, Issue 2, pp. 129-143, (2017) (PubMed).

Li, Cai, Yang, Zhang, Sun, Yan, Qu, Wang, Wang, Duan: "Perichondrium mesenchymal stem cells inhibit the growth of breast cancer cells via the DKK-1/Wnt/β-catenin signaling pathway." in: Oncology reports, Vol. 36, Issue 2, pp. 936-44, (2017) (PubMed).

Naderi-Meshkin, Matin, Heirani-Tabasi, Mirahmadi, Irfan-Maqsood, Edalatmanesh, Shahriyari, Ahmadiankia, Moussavi, Bidkhori, Bahrami: "Injectable hydrogel delivery plus preconditioning of mesenchymal stem cells: exploitation of SDF-1/CXCR4 axis towards enhancing the efficacy of stem cells' homing." in: Cell biology international, (2015) (PubMed).

Fan, Chen, Ni, Wang, Sun, Chen, Zheng: "Expression of MMP-1/PAR-1 and patterns of invasion in oral squamous cell carcinoma as potential prognostic markers." in: OncoTargets and therapy, Vol. 8, pp. 1619-26, (2015) (PubMed).

Tepekoy, Ozturk, Sozen, Ozay, Akkoyunlu, Demir: "CD90 and CD105 expression in the mouse ovary and testis at different stages of postnatal development." in: Reproductive biology, Vol. 15, Issue 4, pp. 195-204, (2015) (PubMed).

Boopathy, Pendergrass, Che, Yoon, Davis: "Oxidative stress-induced Notch1 signaling promotes cardiogenic gene expression in mesenchymal stem cells." in: Stem cell research & therapy, Vol. 4, Issue 2, pp. 43, (2014) (PubMed).

Gao, Zhang, Ding, Chen, Hu, Jiang, Li, Chen, Wang, Ye, Zhu: "Common expression of stemness molecular markers and early cardiac transcription factors in human Wharton's jelly-derived mesenchymal stem cells and embryonic stem cells." in: Cell transplantation, Vol. 22, Issue 10, pp. 1883-900, (2014) (PubMed).

Target Details for Endoglin

Target: Endoglin (ENG)

Alternative Name: CD105 (ENG Products)

Synonyms: ENG antibody, MGC137842 antibody, DKFZp469D0419 antibody, END antibody, HHT1 antibody, ORW1 antibody, AI528660 antibody, AI662476 antibody, CD105 antibody, S-endoglin antibody, endoglin antibody, ENG antibody, Eng antibody

Background:

Synonyms: END, HHT1, ORW1, Endoglin, CD15, ENG

Background: Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3.

Gene ID: 2022

UniProt: P17813