WWOX antibody (AA 5-100)

Catalog No. ABIN670551

Product Details anti-WWOX Antibody

Target: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Binding Specificity: AA 5-100

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WWOX antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human WWOX

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-WWOX antibody (ABIN670551)

Zhang, Zhang, Cong, Zhang: "The ectopic expression of BRCA1 is associated with genesis, progression, and prognosis of breast cancer in young patients." in: Diagnostic pathology, Vol. 7, pp. 181, (2013) (PubMed).

Target Details for WWOX

Target: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Alternative Name: WWOX (WWOX Products)

Synonyms: CG7221 antibody, DmWWOX antibody, Dmel\\CG7221 antibody, anon-EST:Posey177 antibody, GB11795 antibody, WWOX antibody, D16S432E antibody, FOR antibody, FRA16D antibody, HHCMA56 antibody, PRO0128 antibody, SDR41C1 antibody, WOX1 antibody, zgc:55975 antibody, 5330426P09Rik antibody, 9030416C10Rik antibody, WW domain containing oxidoreductase antibody, WW domain-containing oxidoreductase antibody, Wwox antibody, LOC411815 antibody, WWOX antibody, CpipJ_CPIJ004939 antibody, MCYG_01584 antibody, VDBG_05631 antibody, VDBG_01326 antibody, VDBG_06753 antibody, Tsp_03967 antibody, LOC100284583 antibody, wwox antibody

Background:

Synonyms: FOR, WOX1, EIEE28, FRA16D, SCAR12, HHCMA56, PRO0128, SDR41C1, D16S432E, WW domain-containing oxidoreductase, Fragile site FRA16D oxidoreductase, Short chain dehydrogenase/reductase family 41C member 1, WWOX

Background: Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.

Gene ID: 51741

UniProt: Q9NZC7