Add to Basket
Order hotline:
 |
+1 404 474 4654 |
 |
+1 888 205 9894 (TF) |
ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) antibody (PE)
| Antigen | ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) |
| Synonyms | MRX, MXR, ABCP, BCRP, BMDP, MXR1, ABC15, BCRP1, CD338, CDw338, EST157481, MGC102821, Bcrp1, AI428558, ABCG2, MGC127688, bcrp |
| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human, Rat (Rattus), Mouse (Murine) |
| Conjugate |
Alternatives PE |
| Application |
Alternatives Flow Cytometry (FACS), Immunofluorescence (IF)
|
| Catalog no. | ABIN671611 |
| Quantity | 100 µg (1mg/1ml) |
| Price | 330.00 $ Plus shipping costs $35.00 |
| Shipping to |
|
| Availability | Ships within 10 to 15 Business Days |
Additional Information
| Alternative name | ABCG2 |
| Immunogen | Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human ABCG2 |
| Format | Lyophilized |
| Reconstitution | Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%) |
| Isotype | IgG |
| Description | Synonym: BCRP, BXP-21, ABC15, ABCG 2, ABCG2, ABCP, ATP-binding cassette sub-family G member 2, BCRP1, BMDP, Breast cancer resistance protein, CDw338, CDw338, CD338, antigen, EST157481, MGC102821, Mitoxantrone resistance associated protein, MRX, MXR, MXR1, Placenta-specific ATP-binding cassette transporter. |
| Specificity | Excitation / Emission Wavelengths: 565nm/578nm |
| Molecular Weight | 72kDa |
| Comments |
An ABC transporter. Allows efflux of Hoechst dye a property that has been used to separate bone marrow side population cells which express BCRP/ABCG2. Appears to play a major role in the multidrug resistance phenotype of a specific MCF-7 breast cancer cell line. When overexpressed the transfected cells become resistant to mitoxantrone daunorubicin and doxorubicin display diminished intracellular accumulation of daunorubicin and manifest an ATP-dependent increase in the efflux of rhodamine 123.. Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil topotecan or mitoxantrone. |
Application Details
| Application Notes | Flow-Cyt (1:50-200), IF (1:50-200) |
| Concentration | 1mg/1ml |
| Purification | Antibodies are purified by protein A and peptide affinity chromatography. |
| Buffer | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
| Storage | Ship at room temperature. Store at -20°C |
| Research Area | Transporters |
| Restrictions | For Research Use only |
Alternatives
Alternatives for antigen "ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2)", type "Antibodies"
| Hosts | Rabbit (34), Mouse (28), Rat (4) |
| Reactivities | Human (58), Mouse (Murine) (26), Rat (Rattus) (16), Cow (Bovine) (2), Monkey (2), Dog (Canine) (1), Escherichia Coli (E. Coli) (1) |
| Applications | Flow Cytometry (FACS) (39), Western Blotting (WB) (37), Immunofluorescence (IF) (27), Immunohistochemistry (Frozen Sections) (IHC (fro)) (14), ELISA (8), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (7), Enzyme Immunoassay (EIA) (6), Immunohistochemistry (IHC) (4), Immunocytochemistry (ICC) (3), ELISA (Detection) (2), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1) |
| Conjugates | Biotin (4), FITC (2), PE (2), APC (1), Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), Gold (1), HRP (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1) |
| Epitopes | C-Term (2), Center (2) |
