CTGF antibody (AA 221-349)

Catalog No. ABIN672636

Product Details anti-CTGF Antibody

Target: CTGF (Connective Tissue Growth Factor (CTGF))

Binding Specificity: AA 221-349

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTGF antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CTGF

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-CTGF antibody (ABIN672636)

Han, Zhang, Zhong, Wang, Zhang, Chen: "MicroRNA-145 Inhibits Cell Migration and Invasion and Regulates Epithelial-Mesenchymal Transition (EMT) by Targeting Connective Tissue Growth Factor (CTGF) in Esophageal Squamous Cell Carcinoma." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 22, pp. 3925-3934, (2017) (PubMed).

Al-Hamilly, Radwan, Abdul-Rahman, Mourad, Grawish: "Biological roles of KGF, CTGF and TGF-β in cyclosporine-A- and phenytoin- induced gingival overgrowth: A comparative experimental animal study." in: Archives of oral biology, Vol. 66, pp. 38-43, (2016) (PubMed).

Ciamporcero, Shen, Ramakrishnan, Yu Ku, Chintala, Shen, Adelaiye, Miles, Ullio, Pizzimenti, Daga, Azabdaftari, Attwood, Johnson, Zhang, Barrera, Pili: "YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage." in: Oncogene, (2015) (PubMed).

Guo, Zhang, Mu, Liu, Yuan, Ren, Wang: "High-salt intake suppressed microRNA-133a expression in Dahl SS rat myocardium." in: International journal of molecular sciences, Vol. 15, Issue 6, pp. 10794-805, (2015) (PubMed).

Tian, Lv, Yang, Zhang, Yu, Zhu, Xiao, Zhu: "Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats." in: International journal of clinical and experimental pathology, Vol. 7, Issue 6, pp. 3028-37, (2014) (PubMed).

Target Details for CTGF

Target: CTGF (Connective Tissue Growth Factor (CTGF))

Alternative Name: CTGF (CTGF Products)

Synonyms: Ccn2 antibody, Fisp12 antibody, Hcs24 antibody, fisp-12 antibody, CCN2 antibody, HCS24 antibody, IGFBP8 antibody, NOV2 antibody, CTGRP antibody, ctgf antibody, hm:zeh1559 antibody, si:dkey-266k12.4 antibody, wu:fl25c03 antibody, zeh1559 antibody, zgc:136644 antibody, XCTGF antibody, ccn2 antibody, nov2 antibody, hcs24 antibody, igfbp8 antibody, CTGF antibody, si:ch211-173b8.2 antibody, connective tissue growth factor antibody, connective tissue growth factor a antibody, connective tissue growth factor L homeolog antibody, connective tissue growth factor b antibody, Ctgf antibody, CTGF antibody, ctgfa antibody, ctgf.L antibody, ctgf antibody, ctgfb antibody

Background:

Synonyms: CCN2, NOV2, HCS24, IGFBP8, Connective tissue growth factor, CCN family member 2, Hypertrophic chondrocyte-specific protein 24, Insulin-like growth factor-binding protein 8, IBP-8, IGF-binding protein 8, IGFBP-8, CTGF

Background: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

Gene ID: 1490

UniProt: P29279

Pathways: Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Growth Factor Binding