IL23 antibody (AA 101-196)

Catalog No. ABIN673179

Product Details anti-IL23 Antibody

Target: IL23 (Interleukin 23 (IL23))

Binding Specificity: AA 101-196

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL23 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Il23a

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-IL23 antibody (ABIN673179)

Wang, Zhong, Zheng, Li, Chen, Ma, Sun, Yan, Li: "Damage effect of interleukin (IL)-23 on oxygen-glucose-deprived cells of the neurovascular unit via IL-23 receptor." in: Neuroscience, Vol. 289C, pp. 406-416, (2015) (PubMed).

Yang, Gao, Shi, Zhou, Qu, Xu, Shan, Teng: "Effect of iodine excess on Th1, Th2, Th17, and Treg cell subpopulations in the thyroid of NOD.H-2h4 mice." in: Biological trace element research, Vol. 159, Issue 1-3, pp. 288-96, (2014) (PubMed).

Sun, Wang, Fu, Wang, Bi: "A Crucial Role of IL-17 in Bone Resorption During Rejection of Fresh Bone Xenotransplantation in Rats." in: Cell biochemistry and biophysics, (2014) (PubMed).

Target Details for IL23

Target: IL23 (Interleukin 23 (IL23))

Alternative Name: IL-23 (IL23 Products)

Synonyms: IL-23 antibody, p19 antibody, SGRF antibody, il23p19 antibody, interleukin 23, alpha subunit p19 antibody, interleukin 23 subunit alpha antibody, Il23a antibody, IL23A antibody

Background:

Synonyms: P19, SGRF, IL-23, IL-23A, IL23P19, Interleukin-23 subunit alpha, IL-23 subunit alpha, IL-23-A, Interleukin-23 subunit p19, IL-23p19, IL23A, UNQ2498/PRO5798

Background: Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Gene ID: 51561

UniProt: Q9NPF7