CFTR antibody

Antigen: CFTR

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Rat (Rattus), Mouse (Murine), Pig (Porcine), Rabbit, Horse (Equine), Sheep (Ovine), Chicken, Cow (Bovine), Dog (Canine)

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Flow Cytometry (FACS), Immunofluorescence (IF)

Catalog no.: ABIN674304

Additional Information

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human CFTR N-terminus

Format: Lyophilized

Reconstitution: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotype: IgG  (Matching secondary antibodies)

Description: Synonym: ABC 35, ABC35, ABCC 7, ABCC7, ATP binding cassette sub family C member 7, ATP Binding Cassette Superfamily C Member 7, ATP binding cassette transporter sub family C member 7, cAMP dependent chloride channel, CF, CFTR/MRP, Channel conductance controlling ATPase, Cystic fibrosis transmembrane conductance regulator, Cystic fibrosis transmembrane conductance regulator ATP binding cassette sub family C member 7, Cystic Fibrosis Transmembrane Regulator, dJ760C5.1, MRP 7, MRP7, TNR CFTR.

Molecular Weight: 162kDa

Comments:

CFTR (cystic fibrosis transmembrane conductance regulator) the membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1

MDR/TAP

MRP

ALD

OABP

GCN20

White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This gene encodes the cystic fibrosis transmembrane regulator and a chloride channel that controls the regulation of other transport pathways. Mutations in this gene have been associated with autosomal recessive disorders such as cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternative splicing of exons 4

5

and11 have been observed

but full-length transcripts have not yet been fully described. Belongs to the ABC transporter family.

Application Details

Application Notes: WB (1:100-500), ELISA (1:500-1000), IP (1:20-100), IHC-P (1:100-500), IHC-F (1:100-500), Flow-Cyt (1:20-100), IF (1:50-200)

Concentration: 1mg/1ml

Purification: affinity purified by Protein A

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Storage: Ship at room temperature. Store at -20°C

Restrictions: For Research Use only