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OLR1 antibody (AA 201-273)

OLR1 Reactivity: Human, Mouse, Rat, Rabbit WB, ELISA, ICC, FACS, IF (cc), IF (p), IHC (fro), IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN676988
  • Target See all OLR1 Antibodies
    OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))
    Binding Specificity
    • 15
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 201-273
    Reactivity
    • 58
    • 24
    • 21
    • 17
    • 2
    Human, Mouse, Rat, Rabbit
    Host
    • 39
    • 22
    • 2
    • 2
    • 1
    • 1
    Rabbit
    Clonality
    • 44
    • 23
    Polyclonal
    Conjugate
    • 36
    • 6
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This OLR1 antibody is un-conjugated
    Application
    • 46
    • 26
    • 21
    • 13
    • 12
    • 12
    • 11
    • 8
    • 7
    • 7
    • 5
    • 4
    • 3
    • 3
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse, Rabbit, Rat
    Predicted Reactivity
    Cow
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from Rabbit LOX-1
    Isotype
    IgG
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Shibata, Shibata, Maemura, Kondo, Harada-Shiba: "Pathological and molecular analyses of atherosclerotic lesions in ApoE-knockout mice." in: Medical molecular morphology, (2017) (PubMed).

    Gao, Zhao, Li, Lin, Jiang, Wang, Hu, Xu, Peng, He, Zhu: "LOX-1 and TLR4 affect each other and regulate the generation of ROS in A. fumigatus keratitis." in: International immunopharmacology, Vol. 40, pp. 392-399, (2016) (PubMed).

    Deng, Hu, Xin, Gang: "Resveratrol alleviates vascular inflammatory injury by inhibiting inflammasome activation in rats with hypercholesterolemia and vitamin D2 treatment." in: Inflammation research : official journal of the European Histamine Research Society ... [et al.], Vol. 64, Issue 5, pp. 321-32, (2015) (PubMed).

    Li, Zhao, Che, Lin, Li, Hu, Jiang, Liu: "The Role of LOX-1 in Innate Immunity to Aspergillus fumigatus in Corneal Epithelial Cells." in: Investigative ophthalmology & visual science, Vol. 56, Issue 6, pp. 3593-603, (2015) (PubMed).

    Wu, Tang, Jiang, Li, Jiang, Liu: "PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway." in: Molecular and cellular biochemistry, Vol. 359, Issue 1-2, pp. 347-58, (2011) (PubMed).

    Jeng, Dyson: "Direct measurement of the aspartic acid 26 pKa for reduced Escherichia coli thioredoxin by 13C NMR." in: Biochemistry, Vol. 35, Issue 1, pp. 1-6, (1996) (PubMed).

  • Target
    OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))
    Alternative Name
    LOX 1 (OLR1 Products)
    Synonyms
    OLR1 antibody, LOX1 antibody, Olr1 antibody, CLEC8A antibody, LOXIN antibody, SCARE1 antibody, SLOX1 antibody, LOX-1 antibody, SR-EI antibody, Scare1 antibody, Oldlr1 antibody, Oldr1 antibody, PLOX-1 antibody, oxidized low density lipoprotein receptor 1 antibody, oxidized low density lipoprotein (lectin-like) receptor 1 antibody, OLR1 antibody, Olr1 antibody
    Background

    Synonyms: LOX1, LOX-1, Oxidized low-density lipoprotein receptor 1, Ox-LDL receptor 1, Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL receptor 1, Lectin-type oxidized LDL receptor 1, OLR1

    Background: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity).

    Gene ID
    100009322
    UniProt
    Q9XTA8
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