Klotho (KL) antibody (RBITC)
| Antigen |
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| Synonyms |
alpha-kl, KL, Kitl, LOC100223456 |
| Clonality |
Polyclonal |
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Host
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Reactivity
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 Alternatives Human, Mouse (Murine), Rat (Rattus), Rabbit, Cow (Bovine), Horse (Equine), Pig (Porcine), Dog (Canine)
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Conjugate
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Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
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Application
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| Catalog no. |
ABIN681792 |
| Quantity |
100 µg (1mg/1ml) |
| Price |
290.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 10 to 15 Business Days |
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Alternative name
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Klotho
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Immunogen
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Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human Klotho
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Format
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Lyophilized
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Reconstitution
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Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)
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Isotype
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IgG
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Description
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Synonym: KL antibody KLOT_HUMAN, Klotho peptide.
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Specificity
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Excitation / Emission Wavelengths: 495nm/519nm
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Molecular Weight
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111kDa
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Comments
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May have weak glycosidase activity towards glucuronylated steroids. However it lacks essential active site Glu residues at positions 239 and 872 suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1._x000D_ The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.
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Application Notes
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Flow-Cyt (1:50-200), IF (1:50-200)
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Concentration
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1mg/1ml
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Purification
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Antibodies are purified by protein A and peptide affinity chromatography.
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Buffer
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0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
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Storage
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Ship at room temperature. Store at -20°C
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Research Area
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Metabolism
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Restrictions
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For Research Use only
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Alternatives for antigen "Klotho (KL)", type "Antibodies"
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Hosts
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Rabbit (26), Goat (4), Rat (1)
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Reactivities
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Human (24), Mouse (Murine) (18), Rat (Rattus) (16), Cow (Bovine) (15), Dog (Canine) (14), Horse (Equine) (14), Pig (Porcine) (14), Rabbit (14)
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Applications
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Flow Cytometry (FACS) (18), Immunofluorescence (IF) (17), Western Blotting (WB) (11), ELISA (6), Enzyme Immunoassay (EIA) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (2), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
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Conjugates
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Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
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Epitopes
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C-Term (2)
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