SQSTM1 antibody (Sequestosome 1) (AA 80-130)

Details for Product anti-SQSTM1 Antibody No. ABIN682153, Supplier: Log in to see
Antigen
  • SQSTM1
  • sqstm1
  • MGC79491
  • A170
  • OSIL
  • PDB3
  • ZIP3
  • p60
  • p62
  • p62B
  • OSF-6
  • Osi
  • STAP
  • ZIP
  • sb:cb621
  • zgc:85784
  • sequestosome 1
  • sqstm1 protein
  • SQSTM1
  • LOC100342157
  • sqstm1
  • Sqstm1
Alternatives
anti-Human SQSTM1 antibody for Immunohistochemistry (Frozen Sections)
Epitope
AA 80-130
52
40
22
19
19
18
18
18
17
17
14
14
12
11
8
8
6
5
5
5
4
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
331
151
100
8
5
5
5
4
4
2
2
2
2
2
1
1
1
1
1
1
Host
Rabbit
256
68
4
3
Clonality
Polyclonal
Conjugate
This SQSTM1 antibody is un-conjugated
18
17
17
11
10
10
8
8
8
6
6
5
5
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
264
138
96
85
80
64
52
35
33
14
12
4
4
3
2
Options
Supplier
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Immunogen KLH conjugated synthetic peptide derived from human SQSTM1/Ubiquitin-binding protein p62
Isotype IgG
Purification Purified by Protein A.
Alternative Name Sqstm1 (SQSTM1 Antibody Abstract)
Background

Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.

Subcellular location: Cytoplasm, Nucleus

Synonyms: p60, p62, A170, OSIL, PDB3, ZIP3, p62B, Sequestosome-1, EBI3-associated protein of 60 kDa, EBIAP, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62, SQSTM1, ORCA

Gene ID 8878
UniProt Q13501
Pathways NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
ELISA image for anti-Sequestosome 1 (SQSTM1) (AA 80-130) antibody (ABIN682153) 0.2 µg/100 µL Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:3...
Immunohistochemistry (IHC) image for anti-Sequestosome 1 (SQSTM1) (AA 80-130) antibody (ABIN682153) Formalin-fixed and paraffin embedded rat brain labeled with Anti-SQSTM1 Polyclonal An...
SDS-PAGE (SDS) image for anti-Sequestosome 1 (SQSTM1) (AA 80-130) antibody (ABIN682153) L1 rat kidney lysates, L2 rat brain lysates probed : Anti-GDF9 (ABIN682153) at 1:200 ...
Western Blotting (WB) image for anti-Sequestosome 1 (SQSTM1) (AA 80-130) antibody (ABIN682153) HeLa cell lysates probed with Anti-SQSTM1 Polyclonal Antibody, Unconjugated at 1:500...
Western Blotting (WB) image for anti-Sequestosome 1 (SQSTM1) (AA 80-130) antibody (ABIN682153) L1 rat kidney lysates, L2 rat brain lysates probed : Anti-GDF9 at 1:200 in 4˚C. Foll...
Product cited in: Kuo, Weng, Chang, Huang, Lin, Chuang, Lin, Liou, Tai, Lin, Wang: "Altered mitochondrial dynamics and response to insulin in cybrid cells harboring a diabetes-susceptible mitochondrial DNA haplogroup." in: Free radical biology & medicine, Vol. 96, pp. 116-29, 2016 (PubMed).

Xia, Gao, Zhang, Wang, Zhao, Che, Ao, Yang, Wang, Lei: "Autophagy mediated by arginine depletion activation of the nutrient sensor GCN2 contributes to interferon-γ-induced malignant transformation of primary bovine mammary epithelial cells." in: Cell death discovery, Vol. 2, pp. 15065, 2016 (PubMed).

Cui, Luo, Li, Li, Wang: "Changes of intracellular Ca2+ in quercetin-induced autophagy progression." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 11, pp. 908-14, 2015 (PubMed).

Chen, Wei, Nie, Lin, Tian, Liu, Yu, Cheng, Yan, Wang, Liu, Deng, Lai, Zhou, Zhang, Lin, Chen: "?-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in asenescence-accelerated prone 8 mice." in: Brain research, Vol. 1552, pp. 41-54, 2014 (PubMed).

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