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Syncytin A (SYNA) (AA 451-538) antibody (HRP)

SYNA Reactivity: Human, Mouse WB, ELISA Host: Rabbit Polyclonal HRP
Catalog No. ABIN682327
  • Target See all Syncytin A (SYNA) Antibodies
    Syncytin A (SYNA)
    Binding Specificity
    • 2
    • 1
    AA 451-538
    Reactivity
    • 15
    • 5
    • 3
    Human, Mouse
    Host
    • 18
    Rabbit
    Clonality
    • 18
    Polyclonal
    Conjugate
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    HRP
    Application
    • 18
    • 8
    • 6
    • 3
    Western Blotting (WB), ELISA
    Cross-Reactivity
    Human, Mouse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Syncytin 1
    Isotype
    IgG
    Top Product
    Discover our top product SYNA Primary Antibody
  • Application Notes
    WB 1:300-5000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handling Advice
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    Syncytin A (SYNA)
    Alternative Name
    Syncytin 1 (SYNA Products)
    Synonyms
    Gm453 antibody, Gm52 antibody, syncytin-A antibody, syncytin a antibody, Syna antibody
    Background

    Synonyms: ENV, ENVW, HERVW, ERVWE1, HERV7Q, HERV-7q, HERVWENV, HERV-W-ENV, Syncytin-1, Endogenous retrovirus group W member 1, Env-W, Envelope polyprotein gPr73, Enverin, HERV-7q Envelope protein, HERV-W envelope protein, HERV-W_7q21.2 provirus ancestral Env polyprotein, Syncytin, ERVW-1

    Background: This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904). Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein. The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes.

    Gene ID
    30816
    UniProt
    Q9UQF0
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