BCL2 antibody (B-Cell CLL/lymphoma 2) (AA 43-93)

Details for Product anti-BCL2 Antibody No. ABIN683428, Supplier: Log in to see
Antigen
  • Bcl-2
  • PPP1R50
  • bcl-2
  • AW986256
  • C430015F12Rik
  • D630044D05Rik
  • D830018M01Rik
  • BCL-2
  • Bcl2
  • B-cell CLL/lymphoma 2
  • B cell leukemia/lymphoma 2
  • B-cell leukemia/lymphoma 2
  • B-cell leukemia/lymphoma 2-like
  • B-cell CLL/lymphoma 2 protein
  • BCL2
  • Bcl2
  • LOC100224888
  • bcl2
  • LOC100359045
  • BCL-2
Alternatives
anti-Human BCL2 antibody for Flow Cytometry
Epitope
AA 43-93, pSer70
164
75
65
62
44
33
25
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24
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18
15
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13
11
9
9
6
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5
5
5
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3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
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1
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1
1
1
1
1
1
1
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Reactivity
Mouse (Murine), Rat (Rattus)
1033
256
211
54
28
22
18
18
5
4
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2
2
2
2
Host
Rabbit
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536
19
6
2
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2
Clonality
Polyclonal
Conjugate
This BCL2 antibody is un-conjugated
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13
7
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2
2
1
1
1
1
1
1
1
1
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1
Application
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
814
380
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329
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169
80
40
15
14
12
12
11
9
4
3
2
1
1
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen KLH conjugated synthetic phosphopeptide derived from rat Bcl-2 around the phosphorylation site of Ser70
Isotype IgG
Purification Purified by Protein A.
Alternative Name Bcl-2 (BCL2 Antibody Abstract)
Background

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

Subcellular location: Cytoplasm

Synonyms: Bcl-2, Apoptosis regulator Bcl-2, Bcl2

Gene ID 24224
UniProt P49950
Research Area Cancer, Apoptosis/Necrosis
Pathways MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 43-93), (pSer70) antibody (ABIN683428) Formalin-fixed and paraffin embedded rat kidney labeled with Rabbit Anti Phospho-Bcl-...
Western Blotting (WB) image for anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 43-93), (pSer70) antibody (ABIN683428) Mouse spleen lysates probed with Anti-Bcl-2 (Ser70) Polyclonal Antibody, Unconjugated...
Western Blotting (WB) image for anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 43-93), (pSer70) antibody (ABIN683428) Image submitted by OWL Validation Program. 20 μg proteins of cell lysates from A431, ...
Product cited in: Yan, Yuan, Gao, Huang, Ma, Gao, Zhang, Guo, Chen: "Overexpression of Human E46K Mutant ?-Synuclein Impairs Macroautophagy via Inactivation of JNK1-Bcl-2 Pathway." in: Molecular neurobiology, Vol. 50, Issue 2, pp. 685-701, 2014 (PubMed). (1:50).

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