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Claudin 1 antibody (AA 121-211)

CLDN1 Reactivity: Human, Rat, Mouse WB, ELISA, IHC (p), IF (p), FACS, IF (cc), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN686407
  • Target See all Claudin 1 (CLDN1) Antibodies
    Claudin 1 (CLDN1)
    Binding Specificity
    • 15
    • 15
    • 7
    • 7
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 121-211
    Reactivity
    • 89
    • 50
    • 50
    • 22
    • 13
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Rat, Mouse
    Host
    • 81
    • 9
    Rabbit
    Clonality
    • 82
    • 8
    Polyclonal
    Conjugate
    • 47
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This Claudin 1 antibody is un-conjugated
    Application
    • 79
    • 40
    • 29
    • 23
    • 16
    • 16
    • 13
    • 12
    • 8
    • 6
    • 3
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from mouse Claudin 1
    Isotype
    IgG
    Top Product
    Discover our top product CLDN1 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Wang, Chen, Liang, Yan, Lin, Liu, Luo, Huang, Li, Liu, Tang: "Notch inhibition promotes fetal liver stem/progenitor cells differentiation into hepatocytes via the inhibition of HNF-1?." in: Cell and tissue research, Vol. 357, Issue 1, pp. 173-84, (2014) (PubMed).

  • Target
    Claudin 1 (CLDN1)
    Alternative Name
    Claudin 1 (CLDN1 Products)
    Synonyms
    CLD1 antibody, ILVASC antibody, SEMP1 antibody, AI596271 antibody, cldn19 antibody, claudin-1 antibody, cld1 antibody, ilvasc antibody, semp1 antibody, CLDN1 antibody, claudin 1 antibody, claudin 1 S homeolog antibody, CLDN1 antibody, Cldn1 antibody, cldn1 antibody, cldn1.S antibody
    Background

    Synonyms: AI596271, Claudin-1, Cldn1

    Background: Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.

    Gene ID
    12737
    UniProt
    O88551
    Pathways
    Cell-Cell Junction Organization, Hepatitis C
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