Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) (AA 1051-1280) antibody

ABCB1B Reactivity: Human, Mouse, Rat ELISA, WB, FACS, IF (cc), IF (p), IHC (fro), IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN686977
  • Target See all ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) Antibodies
    ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B)
    Binding Specificity
    • 15
    • 8
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1051-1280
    Reactivity
    • 31
    • 23
    • 23
    • 4
    • 4
    • 4
    • 4
    Human, Mouse, Rat
    Host
    • 34
    • 13
    Rabbit
    Clonality
    • 34
    • 13
    Polyclonal
    Conjugate
    • 12
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Un-conjugated
    Application
    • 22
    • 19
    • 17
    • 13
    • 13
    • 6
    • 4
    • 3
    • 3
    • 3
    • 1
    ELISA, Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MDR1
    Isotype
    IgG
    Top Product
    Discover our top product ABCB1B Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Mo, Pospichalova, Huang, Murphy, Payne, Wang, Kennedy, Cianciolo, Bryja, Pizzo, Bachelder: "Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells." in: PLoS ONE, Vol. 10, Issue 7, pp. e0131579, (2015) (PubMed).

  • Target
    ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B)
    Alternative Name
    MDR1 (ABCB1B Products)
    Synonyms
    ABC20 antibody, CD243 antibody, CLCS antibody, GP170 antibody, MDR1 antibody, P-GP antibody, PGY1 antibody, Abcb1 antibody, Mdr1 antibody, Mdr1b antibody, Pgy-1 antibody, Pgy1 antibody, mdr antibody, ATP binding cassette subfamily B member 1 antibody, ATP-binding cassette, sub-family B (MDR/TAP), member 1B antibody, ATP-binding cassette, subfamily B (MDR/TAP), member 1B antibody, ABCB1 antibody, Abcb1b antibody
    Background

    Synonyms: P-Glycoprotein, Multi Drug Resistance Associated Protein, ABCB1, ATP-binding cassette sub-family B MDR/TAP, member 1, ABC20, CD243, CD243 antigen, CLCS, Multidrug resistance protein 1, P glycoprotein 1, p-GP, gp170, P gp, PGY1.

    Background: P Glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas.

    Gene ID
    5243
You are here:
Support