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FLASH antibody (AA 1861-1982)

CASP8AP2 Reactivity: Mouse WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN702220
  • Target See all FLASH (CASP8AP2) Antibodies
    FLASH (CASP8AP2) (CASP8 Associated Protein 2 (CASP8AP2))
    Binding Specificity
    • 3
    • 3
    • 1
    • 1
    • 1
    AA 1861-1982
    Reactivity
    • 17
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Mouse
    Host
    • 18
    Rabbit
    Clonality
    • 18
    Polyclonal
    Conjugate
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FLASH antibody is un-conjugated
    Application
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Mouse
    Predicted Reactivity
    Human,Rat,Dog,Cow,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FLASH/CASP8AP2
    Isotype
    IgG
    Top Product
    Discover our top product CASP8AP2 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    FLASH (CASP8AP2) (CASP8 Associated Protein 2 (CASP8AP2))
    Alternative Name
    FLASH/CASP8AP2 (CASP8AP2 Products)
    Synonyms
    CASP8AP2 antibody, FLASH antibody, fc74h10 antibody, wu:fc74h10 antibody, zgc:113449 antibody, CED-4 antibody, RIP25 antibody, AA387232 antibody, D4Ertd659e antibody, mKIAA1315 antibody, caspase 8 associated protein 2 antibody, CASP8AP2 antibody, casp8ap2 antibody, Casp8ap2 antibody
    Background

    Synonyms: CASP 8 associated protein 2, CASP8 associated protein 2, CASP8AP2, Caspase 8 associated protein 2, CED 4, CED4, FLASH homolog, FLASH homolog RIP 25, FLASH homolog RIP25, FLICE associated huge, FLICE associated huge protein, FLICE-associated huge protein, RIP 25, RIP25, AA387232, D4Ertd659e, mKIAA1315, C8AP2_HUMAN, CASP8-associated protein 2, FLICE-associated huge protein, FLJ11208, KIAA1315, OTTMUSP00000005125, RP23-69G24.1.

    Background: FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8. There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity.Studies of FLASH protein suggested that this protein may be a component of the death inducing signaling complex that includes Fas receptor, Fas binding adapter FADD, and caspase 8, and plays a regulatory role in Fas mediated apoptosis.

    Gene ID
    9994
    Pathways
    Chromatin Binding, Positive Regulation of Endopeptidase Activity
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