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Autophagy/beclin-1 Regulator 1 (AMBRA1) antibody (Gold)
| Antigen | Autophagy/beclin-1 Regulator 1 (AMBRA1) |
| Synonyms | Ambra1, AA474864, AV021921, mKIAA1736, A130023A14, RP23-273F8.1, 2310079H06Rik, D030051N19Rik, DCAF3, WDR94, FLJ20294, KIAA1736, MGC33725, AMBRA1, MGC128737 |
| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human, Mouse (Murine), Rat (Rattus), Rabbit, Dog (Canine), Horse (Equine), Chicken |
| Conjugate |
Alternatives Gold |
| Application |
Alternatives Immunoelectron Microscopy (IEM)
|
| Catalog no. | ABIN704749 |
| Quantity | 100 µg (1mg/1ml) |
| Price | 350.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 10 to 15 Business Days |
Additional Information
| Alternative name | AMBRA1 |
| Immunogen | Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human AMBRA1 N-terminus |
| Format | Lyophilized |
| Reconstitution | Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%) |
| Isotype | IgG |
| Description | Synonym: Activating molecule in beclin 1 regulated autophagy, Activating molecule in BECN1 regulated autophagy protein 1, Hypothetical protein FLJ20294, Hypothetical protein LOC55626, KIAA1736, MGC33725, WDR94. |
| Molecular Weight | 143kDa |
| Comments |
AMBRA1 regulates autophagy and development of the nervous system. It is a large previously unknown protein bearing a WD40 domain at its amino terminus regulates autophagy and has a crucial role in embryogenesis. AMBRA1 is a positive regulator of the Becn1-dependent programme of autophagy as revealed by its overexpression and by RNA interference experiments invitro. Notably AMBRA1 functional deficiency in mouse embryos leads to severe neural tube defects associated with autophagy impairment accumulation of ubiquitinated proteins unbalanced cell proliferation and excessive apoptotic cell death. |
Application Details
| Application Notes | Electron Microscopy (1:100-500) |
| Concentration | 1mg/1ml |
| Purification | Antibodies are purified by protein A and peptide affinity chromatography. |
| Buffer | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
| Storage | Ship at room temperature. Store at -20°C |
| Research Area | Cancer, Autophagy, Neurogenesis |
| Restrictions | For Research Use only |
Alternatives
Alternatives for antigen "Autophagy/beclin-1 Regulator 1 (AMBRA1)", type "Antibodies"
| Hosts | Rabbit (31) |
| Reactivities | Human (28), Mouse (Murine) (23), Rat (Rattus) (21), Chicken (15), Dog (Canine) (15), Horse (Equine) (15), Rabbit (15), Cow (Bovine) (3), Pig (Porcine) (1) |
| Applications | Flow Cytometry (FACS) (18), Immunofluorescence (IF) (18), Western Blotting (WB) (15), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (7), Immunohistochemistry (IHC) (6), ELISA (4), Enzyme Immunoassay (EIA) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunoprecipitation (IP) (2) |
| Conjugates | Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1) |
| Epitopes | C-Term (3), N-Term (2), internal (2) |
