RHOBTB2 antibody (AA 631-727)

Catalog No. ABIN706241

Product Details anti-RHOBTB2 Antibody

Target: RHOBTB2 (rho-Related BTB Domain Containing 2 (RHOBTB2))

Binding Specificity: AA 631-727

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RHOBTB2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DBC2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for RHOBTB2

Target: RHOBTB2 (rho-Related BTB Domain Containing 2 (RHOBTB2))

Alternative Name: DBC2 (RHOBTB2 Products)

Synonyms: DBC2 antibody, Dbc2 antibody, E130206H14Rik antibody, mKIAA0717 antibody, Rho related BTB domain containing 2 antibody, Rho-related BTB domain containing 2 antibody, RHOBTB2 antibody, Rhobtb2 antibody

Background:

Synonyms: DBC2, Rho-related BTB domain-containing protein 2, Deleted in breast cancer 2 gene protein, p83, RHOBTB2, KIAA0717

Background: DBC2 is a member of the recently identified RhoBTB family, which is part of the Rho GTPase family. DBC2 has been implicated as a tumor suppressor in breast and lung cancer. Studies have shown that DBC2 binds to the ubiquitin ligase scaffold Cul3, and that Cul3 regulates DBC2 protein levels by ubiquitinating DBC2 directly, leading to its degradation by the proteasome.

Gene ID: 23221

UniProt: Q9BYZ6