SIGMAR1 antibody (AA 21-120)

Catalog No. ABIN709841

Product Details anti-SIGMAR1 Antibody

Target: SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))

Binding Specificity: AA 21-120

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIGMAR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human OPRS1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SIGMAR1

Target: SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))

Alternative Name: OPRS1 (SIGMAR1 Products)

Synonyms: ALS16 antibody, OPRS1 antibody, SIG-1R antibody, SR-BP antibody, SR-BP1 antibody, SRBP antibody, sigma1R antibody, AL024364 antibody, Oprs1 antibody, mSigmaR1 antibody, Sigma1R antibody, oprs1 antibody, zgc:56378 antibody, sigma non-opioid intracellular receptor 1 antibody, sigma non-opioid intracellular receptor 1 L homeolog antibody, SIGMAR1 antibody, Sigmar1 antibody, sigmar1.L antibody, sigmar1 antibody

Background:

Synonyms: SRBP, ALS16, OPRS1, SR-BP, SIG-1R, SR-BP1, sigma1R, hSigmaR1, Sigma non-opioid intracellular receptor 1, Aging-associated gene 8 protein, SR31747-binding protein, Sigma 1-type opioid receptor, Sigma1-receptor, SIGMAR1, AAG8

Background: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.

Gene ID: 10280

UniProt: Q99720

Pathways: SARS-CoV-2 Protein Interactome