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TUSC2 antibody (AA 31-100) (HRP)

TUSC2 Reactivity: Human WB, ELISA, IHC (p), IHC (fro) Host: Rabbit Polyclonal HRP
Catalog No. ABIN713555
  • Target See all TUSC2 Antibodies
    TUSC2 (Tumor Suppressor Candidate 2 (TUSC2))
    Binding Specificity
    • 14
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 31-100
    Reactivity
    • 29
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 27
    • 2
    • 1
    Rabbit
    Clonality
    • 29
    • 1
    Polyclonal
    Conjugate
    • 17
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TUSC2 antibody is conjugated to HRP
    Application
    • 27
    • 14
    • 13
    • 13
    • 9
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human TUSC2
    Isotype
    IgG
    Top Product
    Discover our top product TUSC2 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handling Advice
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    TUSC2 (Tumor Suppressor Candidate 2 (TUSC2))
    Alternative Name
    TUSC2 (TUSC2 Products)
    Synonyms
    C3orf11 antibody, FUS1 antibody, PAP antibody, PDAP2 antibody, TUSC2 antibody, 1190001E22Rik antibody, AA407686 antibody, Fus1 antibody, Lgcc antibody, Pdap2 antibody, zgc:92701 antibody, zgc:153746 antibody, tumor suppressor candidate 2 antibody, tumor suppressor candidate 2 L homeolog antibody, tumor suppressor candidate 2b antibody, tumor suppressor candidate 2a antibody, TUSC2 antibody, tusc2.L antibody, Tusc2 antibody, tusc2b antibody, tusc2a antibody
    Background

    Synonyms: C3orf11, FUS1, Fusion 1 protein, PAP, PDAP2, PDGFA associated protein 2, Tumor suppressor candidate 2, TUSC 2, TUSC2_HUMAN.

    Background: TUSC2/FUS1 is a novel tumor suppressor gene identified in the human chromosome 3p21.3 region where allele losses and genetic alterations occur early and frequently for many human cancers. Expression of TUSC2 protein is absent or reduced in the majority of lung cancers and premalignant lung lesions. Restoration of TUSC2 function in 3p21.3-deficient non-small cell lung carcinoma cells significantly inhibits tumor cell growth by induction of apoptosis and alteration of cell cycle kinetics. TUSC2 may induce apoptosis through the activation of the intrinsic mitochondrial-dependent and Apaf-1-associated pathways and inhibit the function of protein tyrosine kinases including EGFR, PDGFR, AKT, c-Abl, and c-Kit.

    Gene ID
    11334
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