MAPK8IP1 antibody (Mitogen-Activated Protein Kinase 8 Interacting Protein 1)

Details for Product anti-MAPK8IP1 Antibody No. ABIN716441, Supplier: Log in to see
Antigen
  • IB1
  • JIP-1
  • Jip1
  • Prkm8ip
  • Skip
  • mjip-2a
  • JIP1
  • Jip-1
  • Mapk8ip
  • PRKM8IP
  • mitogen-activated protein kinase 8 interacting protein 1
  • MAPK8IP1
  • LOC100344706
  • Mapk8ip1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
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45
39
Host
Rabbit
69
2
1
Clonality
Polyclonal
Conjugate
This MAPK8IP1 antibody is un-conjugated
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3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
56
31
17
12
8
7
4
3
2
2
1
Options
Supplier
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Immunogen KLH conjugated synthetic peptide derived from human JIP1/MAPK8IP1
Isotype IgG
Purification Purified by Protein A.
Alternative Name Mapk8ip1 (MAPK8IP1 Antibody Abstract)
Background

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.

Subcellular location: Cytoplasm

Synonyms: IB1, JIP1, JIP-1, PRKM8IP, C-Jun-amino-terminal kinase-interacting protein 1, JNK-interacting protein 1, Islet-brain 1, IB-1, JNK MAP kinase scaffold protein 1, Mitogen-activated protein kinase 8-interacting protein 1, MAPK8IP1

Gene ID 9479
UniProt Q9UQF2
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-MAPK8IP1 antibody (Mitogen-Activated Protein Kinase 8 Interacting Protein 1) (ABIN716441) Formalin-fixed and paraffin embedded rat brain labeled with Anti-MAPK8IP1 Polyclonal ...