Sodium Channel, Voltage-Gated, Type I, beta (SCN1B) antibody

Antigen: Sodium Channel, Voltage-Gated, Type I, beta (SCN1B)

Synonyms: GEFSP1

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Flow Cytometry (FACS), Immunofluorescence (IF)

Catalog no.: ABIN719966

Additional Information

Alternative name: SCN1B

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from hu SCN1B

Format: Lyophilized

Reconstitution: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotype: IgG  (Matching secondary antibodies)

Description: Synonym: GEFSP1, SCN1B, SCN1B_HUMAN, sodium channel beta 1 subunit, Sodium channel subunit beta 1, Sodium channel subunit beta-1, Sodium channel voltage gated type I beta.

Molecular Weight: 25kDa

Comments:

Crucial in the assembly

expression

and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain

skeletal muscle

and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.Tissue specificity

Abundantly expressed in skeletal muscle

heart and brain.

Application Details

Application Notes: WB (1:100-500), ELISA (1:500-1000), IP (1:20-100), IHC-P (1:100-500), IHC-F (1:100-500), Flow-Cyt (1:20-100), IF (1:50-200)

Concentration: 1mg/1ml

Purification: affinity purified by Protein A

Buffer: Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

Storage: Ship at room temperature. Store at -20°C

Research Area: Signaling, Metabolism

Restrictions: For Research Use only