Laminin, alpha 5 (LAMA5) antibody

Antigen: Laminin, alpha 5 (LAMA5)

Synonyms: KIAA1907, [a]5, AA408760, AA408762, AI853660, mKIAA0533, laminin-511, cb402, sb:cb402, im:7138247, wu:fb81a10, LAMA5

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Flow Cytometry (FACS), Immunofluorescence (IF)

Catalog no.: ABIN720340

Additional Information

Alternative name: Laminin 5

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from hu Laminin 5

Format: Lyophilized

Reconstitution: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotype: IgG  (Matching secondary antibodies)

Description: Synonym: EBR2A, Epiligrin 170 kDa subunit,Epiligrin subunit alpha, Kalinin B1 chain, Kalinin subunit alpha, LAMA 3, LAMA3, LAMA3_HUMAN, Lama3a, LAMB 3, LAMB2T, LAMB3, LAMC2, Laminin gamma 2, Laminin 5 alpha 3 chain, Laminin 5 beta 3, Laminin 5 gamma 2 subuni, Laminin alpha 3, Laminin beta 3, Laminin beta 3 chain, Laminin gamma 2 chain,Laminin subunit alpha-3,Laminin subunit beta 3, Laminin subunit gamma 2, Laminin-5 subunit alpha, Laminin-6 subunit alpha, Laminin-7 subunit alpha, Laminin5, LAMNA, LAMNB1,LAMNB2, LOCS, Nicein subunit alpha,BM600, E170.

Molecular Weight: 165, 140, 105kDa

Comments:

Binding to cells via a high affinity receptor

laminin is thought to mediate the attachment

migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.v Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes

(2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80

(3) differentiation of keratinocytes.Tissue specificity

Skin

respiratory

urinary

and digestive epithelia and in other specialized tissues with prominent secretory or protective functions. Epithelial basement membrane

and epithelial cell tongue that migrates into a wound bed. A differential and focal expression of the subunit alpha-3 is observed in the CNS.

Application Details

Application Notes: WB (1:100-500), ELISA (1:500-1000), IP (1:20-100), IHC-P (1:100-500), IHC-F (1:100-500), Flow-Cyt (1:20-100), IF (1:50-200)

Concentration: 1mg/1ml

Purification: affinity purified by Protein A

Buffer: Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

Storage: Ship at room temperature. Store at -20°C

Research Area: Cancer, Extracellular Matrix

Restrictions: For Research Use only