ACTH 7-23 antibody

Catalog No. ABIN723485

Product Details

Target: ACTH 7-23

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Pig,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ACTH

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References

Jussila, Huotari-Orava, Ylianttila, Partonen, Snellman: "Narrow-band ultraviolet B radiation induces the expression of β-endorphin in human skin in vivo." in: Journal of photochemistry and photobiology. B, Biology, Vol. 155, pp. 104-8, (2016) (PubMed).

Zhou, Wei, Kuang, Luo, Ma, Zeng, Wang, Liu, Gong, Wang, Lei, Wang, Zeng, Wang, He, Yuan, Dai, He, Xing: "A novel P53/POMC/Gαs/SASH1 autoregulatory feedback loop activates mutated SASH1 to cause pathologic hyperpigmentation." in: Journal of cellular and molecular medicine, Vol. 21, Issue 4, pp. 802-815, (2016) (PubMed).

Target Details

Target: ACTH 7-23

Background:

Synonyms: Adrenocorticotropic hormone, Adrenocorticotropin, Adrenocorticotropin Hormone, Alpha Melanocyte Stimulating Hormone, Beta Endorphin, Beta Lipotropin, Beta Melanocyte Stimulating Hormone, CLIP, Corticotropin, Corticotropin Like Intermediary Peptide, Corticotropin lipotropin precursor, Lipotropin Beta, Lipotropin Gamma, LPH, Melanotropin Alpha, Met Enkephalin, MSH, NPP, POC, POMC, Pro opiomelanocortin, Proopiomelanocortin.

Background: ACTH occurs in cells of the anterior pituitary and in neurons in brain. It regulates the corticosteroid production in the adrenal cortex. Beta endorphin and Met enkephalin are endogenous opiates. MSH (melanocyte stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.

Gene ID: 5443

UniProt: P01189