IGF1 antibody (AA 49-100)

Catalog No. ABIN723605

Product Details anti-IGF1 Antibody

Target: IGF1 (Insulin-Like Growth Factor 1 (IGF1))

Binding Specificity: AA 49-100

Reactivity: Human, Mouse, Rat, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IGF1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Dog, Human, Mouse, Rat

Predicted Reactivity: Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IGF-1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
IP(1-2 μg)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-IGF1 antibody (ABIN723605)

Liao, Xiao, Zhu, Zhou: "The effect of celastrol on learning and memory in diabetic rats after sevoflurane inhalation." in: Archives of medical science : AMS, Vol. 14, Issue 2, pp. 370-380, (2018) (PubMed).

Uysal, Agilkaya, Sisman, Camsari, Gencoglu, Dayi, Aksu, Baykara, Cingoz, Kiray: "Exercise increases leptin levels correlated with IGF-1 in hippocampus and prefrontal cortex of adolescent male and female rats." in: Journal of chemical neuroanatomy, Vol. 81, pp. 27-33, (2017) (PubMed).

Gabr, Rateb, El Sissy, Ahmed Seddiek, Ali Abdelhameed Gouda: "The effect of bone marrow-derived mesenchymal stem cells on chemotherapy induced ovarian failure in albino rats." in: Microscopy research and technique, Vol. 79, Issue 10, pp. 938-947, (2016) (PubMed).

Kiray, Sisman, Camsari, Evren, Dayi, Baykara, Aksu, Ates, Uysal: "Effects of carbon dioxide exposure on early brain development in rats." in: Biotechnic & histochemistry : official publication of the Biological Stain Commission, Vol. 89, Issue 5, pp. 371-83, (2014) (PubMed).

Baykara, Aksu, Buyuk, Kiray, Sisman, Baykara, Dayi, Tas, Ozdemir, Arda, Uysal et al.: "Progesterone treatment decreases traumatic brain injury induced anxiety and is correlated with increased serum IGF-1 levels; prefrontal cortex, amygdala, hippocampus neuron density; and reduced serum ..." in: Biotechnic & histochemistry : official publication of the Biological Stain Commission, Vol. 88, Issue 5, pp. 250-7, (2013) (PubMed).

Target Details for IGF1

Target: IGF1 (Insulin-Like Growth Factor 1 (IGF1))

Alternative Name: IGF 1 (IGF1 Products)

Background:

Synonyms: IGFI, IGF-I, IGF1A, Insulin-like growth factor I, Mechano growth factor, MGF, Somatomedin-C, IGF1, IBP1

Background: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation.

Gene ID: 3479

UniProt: P05019

Pathways: RTK Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Hormone Activity, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Activated T Cell Proliferation, Positive Regulation of fat Cell Differentiation