Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 330-358) antibody

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Antigen
  • erk1/2
  • mitogen-activated protein kinase
  • erk1/2
Epitope
AA 330-358
115
104
30
30
28
19
18
17
15
15
15
15
14
12
9
9
9
8
7
7
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
403
312
300
57
24
15
9
8
8
8
7
6
5
5
3
3
2
2
2
1
1
1
1
Host
Rabbit
331
76
6
Clonality
Polyclonal
Conjugate
Un-conjugated
12
11
11
9
7
7
7
6
6
6
6
6
6
6
2
2
2
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
291
106
81
77
60
54
39
38
14
10
6
4
3
2
2
2
2
Options
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Immunogen KLH conjugated synthetic peptide derived from mouse ERK2
Isotype IgG
Purification Purified by Protein A.
Alternative Name ERK1 + ERK2 (MAPK1/3 Antibody Abstract)
Background

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.

Subcellular location: Cytoplasm, Nucleus

Synonyms: Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, Mapk1, Erk2, Mapk, Prkm1

Gene ID 26413
UniProt P63085
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Immunofluorescence (IF) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 330-358) antibody (ABIN723725) Formalin-fixed and paraffin-embedded rat brain labeled with Anti-ERK2/MAPK1 Polyclona...
Immunofluorescence (IF) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 330-358) antibody (ABIN723725) Formalin-fixed and paraffin-embedded rat brain labeled with Anti-ERK2/MAPK1 Polyclona...
Immunohistochemistry (IHC) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 330-358) antibody (ABIN723725) Formalin-fixed and paraffin embedded rat hippocampus labeled with Anti-ERK2/MAPK1 Pol...
SDS-PAGE (SDS) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 330-358) antibody (ABIN723725) L1 rat brain, L2 rat heart lysates probed (ABIN723725) at 1:200 in 4 °C. Followed by ...
Immunohistochemistry (IHC) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 330-358) antibody (ABIN723725) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-ERK2/MAPK...
Western Blotting (WB) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 330-358) antibody (ABIN723725) Mouse placenta lysates probed with ERK1 + ERK2 Polyclonal Antibody, unconjugated at ...
Product cited in: Chu, Zhao, Feng, Zhang, Liu, Cheng, Li, Shen, Cao, Li, Min: "MicroRNA-126 participates in lipid metabolism in mammary epithelial cells." in: Molecular and cellular endocrinology, Vol. 454, pp. 77-86, 2017 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Human).

Sun, Wang, Fu, Chen, Wang, Li, Xing, Li: "Magnolia officinalis Extract Contains Potent Inhibitors against PTP1B and Attenuates Hyperglycemia in db/db Mice." in: BioMed research international, Vol. 2015, pp. 139451, 2015 (PubMed).

Sun, Fu, Liu, Wang, Huo, Guo, Gao, Li, Hu: "Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice." in: Drug design, development and therapy, Vol. 9, pp. 6327-42, 2015 (PubMed).