CNN1 antibody (AA 201-297)

Catalog No. ABIN724820

Product Details anti-CNN1 Antibody

Target: CNN1 (Calponin 1 (CNN1))

Binding Specificity: AA 201-297

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNN1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Calponin 1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-CNN1 antibody (ABIN724820)

Hayashi, Ichimura, Kasai, Sano, Zharhary, Shiozawa, Yaegashi, Konishi: "Characterization of Leiomyomatoid Angiomatous Neuroendocrine Tumour (LANT)-like Tumour in the Myometrium with Histopathological Examination." in: Anticancer research, Vol. 37, Issue 4, pp. 1765-1772, (2017) (PubMed).

Meng, Tong, Liu, Yu, Zhang, Gao: "Epigallocatechin-3-gallate inhibits growth and induces apoptosis in esophageal cancer cells through the demethylation and reactivation of the p16 gene." in: Oncology letters, Vol. 14, Issue 1, pp. 1152-1156, (2017) (PubMed).

Cai, He, Li, Sun, Lam, Qiao, Qiu: "Regulation of tumorigenesis in oral epithelial cells by defined reprogramming factors Oct4 and Sox2." in: Oncology reports, Vol. 36, Issue 2, pp. 651-8, (2016) (PubMed).

Syedain, Meier, Lahti, Johnson, Tranquillo: "Implantation of completely biological engineered grafts following decellularization into the sheep femoral artery." in: Tissue engineering. Part A, Vol. 20, Issue 11-12, pp. 1726-34, (2014) (PubMed).

Zhao, Li, Katzenellenbogen, Lau, Taylor, Bagchi, Bagchi: "Estrogen-Induced CCN1 is Critical for Establishment of Endometriosis-like Lesions in Mice." in: Molecular endocrinology (Baltimore, Md.), pp. me20141080, (2014) (PubMed).

Du, Wang, Zhao, Li, Kong, Yang, Zhang: "Gradient nanofibrous chitosan/poly ?-caprolactone scaffolds as extracellular microenvironments for vascular tissue engineering." in: Biomaterials, Vol. 33, Issue 3, pp. 762-70, (2011) (PubMed).

Target Details for CNN1

Target: CNN1 (Calponin 1 (CNN1))

Alternative Name: Calponin 1 (CNN1 Products)

Synonyms: CN antibody, CnnI antibody, SMCC antibody, Sm-Calp antibody, XclpH3 antibody, clpH3 antibody, cnn2 antibody, calponin 1 antibody, calponin 1, basic, smooth muscle L homeolog antibody, cnn1 antibody, Cnn1 antibody, CNN1 antibody, cnn1.L antibody

Background:

Synonyms: SMCC, Sm-Calp, HEL-S-14, Calponin-1, Basic calponin, Calponin H1, smooth muscle, CNN1

Background: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity).

Molecular Weight: 34kDa

Gene ID: 1264

UniProt: P51911