Caspase 1 (p10) antibody (AA 320-404) (FITC)

Catalog No. ABIN725787

Product Details anti-Caspase 1 (p10) Antibody (FITC)

Target: Caspase 1 (p10) (CASP-1 (p10))

Binding Specificity: AA 320-404

Reactivity: Human, Mouse, Rat, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 1 (p10) antibody is conjugated to FITC

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Chicken, Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Caspase-1

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

References for anti-Caspase 1 (p10) antibody (FITC) (ABIN725787)

Cai, Liu, Luo, Wang, Shen, Shen, Zhang, Chen, Lu: "Caspase-1 Activity in CD4 T Cells Is Downregulated Following Antiretroviral Therapy for HIV-1 Infection." in: AIDS research and human retroviruses, Vol. 33, Issue 2, pp. 164-171, (2016) (PubMed).

Target Details for Caspase 1 (p10)

Target: Caspase 1 (p10) (CASP-1 (p10))

Alternative Name: Caspase-1 P10 (CASP-1 (p10) Products)

Background:

Synonyms: ICE, P45, IL1BC, Caspase-1, CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, IL-1 beta-converting enzyme, CASP1, IL1BCE

Background: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.

Gene ID: 834

UniProt: P29466