Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 140-190) antibody (FITC)

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Antigen
  • AGER
  • RAGE
  • advanced glycosylation end product-specific receptor
  • AGER
  • Ager
  • LOC100343142
Alternatives
anti-Cow (Bovine) Advanced Glycosylation End Product-Specific Receptor antibody for Enzyme Immunoassay
Epitope
AA 140-190
55
31
15
14
10
10
8
7
6
6
5
5
5
5
5
4
3
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Rat (Rattus)
237
125
76
7
5
4
3
3
3
3
1
1
Host
Rabbit
241
30
17
16
2
Clonality
Polyclonal
Conjugate
FITC
18
15
14
8
7
7
4
4
4
4
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
210
128
122
74
35
25
21
12
12
10
4
4
1
1
1
Options
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Immunogen KLH conjugated synthetic peptide derived from rat AGER
Isotype IgG
Purification Purified by Protein A.
Alternative Name RAGE (AGER Antibody Abstract)
Background

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S1A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Interaction with S1B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.

Subcellular location: Extracellular

Synonyms: RAGE, Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products, Ager

Gene ID 81722
UniProt Q63495
Research Area Neurology, Alzheimer's Disease
Pathways Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration
Application Notes FCM 1:20-100
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C
Expiry Date 12 months
Product cited in: Zhu, Yao, Zhang, Dong, Yu, Sheng: "Anti-RAGE antibody ameliorates severe thermal injury in rats through regulating cellular immune function." in: Acta pharmacologica Sinica, Vol. 35, Issue 9, pp. 1167-76, 2014 (PubMed).

Braach, Buschmann, Pflaum, Hudalla, Koch, Ryschich, Poeschl, Frommhold: "Anti-inflammatory functions of protein C require RAGE and ICAM-1 in a stimulus-dependent manner." in: Mediators of inflammation, Vol. 2014, pp. 743678, 2014 (PubMed).

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