DNAJC3 antibody (AA 351-450) (FITC)

Catalog No. ABIN735555

Product Details anti-DNAJC3 Antibody (FITC)

Target: DNAJC3 (DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3))

Binding Specificity: AA 351-450

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNAJC3 antibody is conjugated to FITC

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human p58ipk/DNAJC3

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DNAJC3

Target: DNAJC3 (DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3))

Alternative Name: P58ipk/Dnajc3 (DNAJC3 Products)

Synonyms: ERdj6 antibody, HP58 antibody, P58 antibody, P58IPK antibody, PRKRI antibody, zgc:56356 antibody, zgc:77731 antibody, wu:fb64f06 antibody, DNAJC3 antibody, dnajc3 antibody, DDBDRAFT_0186884 antibody, DDBDRAFT_0233602 antibody, DDB_0186884 antibody, DDB_0233602 antibody, cg8286 antibody, AA408985 antibody, AU067833 antibody, Dnajc3a antibody, Dnajc3b antibody, Prkri antibody, mp58 antibody, p58 antibody, p58IPK antibody, fc17a06 antibody, prkri antibody, wu:fc17a06 antibody, DnaJ heat shock protein family (Hsp40) member C3 antibody, DnaJ (Hsp40) homolog, subfamily C, member 3a antibody, DNAJ heat shock N-terminal domain-containing protein antibody, DnaJ heat shock protein family (Hsp40) member C3 L homeolog antibody, DnaJ (Hsp40) homolog, subfamily C, member 3b antibody, DNAJC3 antibody, dnajc3a antibody, dnajc3 antibody, dnajc3.L antibody, Dnajc3 antibody, dnajc3b antibody

Background:

Synonyms: DNAJC3, Protein Kinase Inhibitor P58, DnaJ homolog subfamily C member 3, HP58, Interferon induced, double stranded RNA activated protein kinase inhibitor, P58, p58 ipk , P58IPK, PRKRI, Protein kinase inhibitor of 58 kDa, Protein kinase inhibitor p58.

Background: DNAJC3 may act as an inhibitor of both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2/PKR to catalyze phosphorylation of the EIF2A. It also functions as a Co-chaperone of HSPA8/HSC70 and is involved in the unfolded protein response (UPR) during ER stress. It has been reported that this protein stimulates the ATPase activity of HSPA8/HSC70.DNAJC3 is also involved in ativiral defense - it is activated in response to infection by influenza virus through the dissociation of DNAJB1. DNAJC3 is widely expressed and can be found at high levels in the testis and pancreas (expression in cell lines is variable).

Gene ID: 5611

UniProt: Q13217

Pathways: ER-Nucleus Signaling