Integrin beta 3 antibody (ITGB3) (AA 27-77)

Details for Product anti-ITGB3 Antibody No. ABIN739029, Supplier: Log in to see
Antigen
  • CD61
  • GP3A
  • INGRB3
  • BDPLT16
  • BDPLT2
  • GPIIIa
  • GT
  • INTB3
  • integrin
  • GPIIIA
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
  • integrin beta 3
  • integrin, beta 3
  • ITGB3
  • Itgb3
Alternatives
anti-Human Integrin beta 3 antibody for Flow Cytometry
Epitope
AA 27-77
49
43
33
24
19
19
17
14
9
8
6
4
4
4
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
602
248
203
28
27
25
24
19
16
13
6
5
4
4
4
3
2
2
2
2
2
2
1
1
1
1
Host
Rabbit
378
237
52
29
28
4
1
Clonality
Polyclonal
Conjugate
This Integrin beta 3 antibody is un-conjugated
78
54
27
22
18
14
13
13
13
10
9
8
8
8
7
7
7
7
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6
6
5
2
2
2
2
2
2
2
Application
ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
440
282
167
136
111
91
81
75
65
26
14
13
12
8
6
5
5
4
2
2
2
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen KLH conjugated synthetic peptide derived from human Integrin beta 3
Isotype IgG
Purification Purified by Protein A.
Alternative Name Integrin beta 3 (ITGB3 Antibody Abstract)
Background

Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Subcellular location: Extracellular

Synonyms: GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16, Integrin beta-3, Platelet membrane glycoprotein IIIa, ITGB3

Molecular Weight 87kDa
Gene ID 3690
UniProt P05106
Research Area Cardiovascular, Atherosclerosis, Angiogenesis, Cell/Tissue Markers, Extracellular Matrix, Signaling
Pathways Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex
Application Notes WB 1:100-1000
ELISA 1:500-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Integrin beta 3 (ITGB3) (AA 27-77) antibody (ABIN739029) Formalin-fixed and paraffin embedded human rectal carcinoma labeled with Anti-Integri...
Western Blotting (WB) image for anti-Integrin beta 3 (ITGB3) (AA 27-77) antibody (ABIN739029) Mouse placenta lysates probed withAnti-Integrin beta 3 Polyclonal Antibody, Unconjuga...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Integrin beta 3 (ITGB3) (AA 27-77) antibody (ABIN739029) Formalin-fixed and paraffin embedded human rectal carcinoma labeled with Anti-Integri...
Flow Cytometry (FACS) image for anti-Integrin beta 3 (ITGB3) (AA 27-77) antibody (ABIN739029) Human HL-60 cells probed with Integrin beta 3 Polyclonal Antibody, Unconjugated (gre...
Product cited in: Zhou, Qu, Sun, Wu, Liu, Yang, Zhang: "Sophoricoside fails the embryo implantation by compromising the uterine endometrial receptivity at implantation "window" of pregnant mice." in: Chemico-biological interactions, Vol. 219C, pp. 57-63, 2014 (PubMed).

Wang, Jiang, Peng, Guo, Shang, Chen, Wu, Chen: "Induced apoptosis of osteoblasts proliferating on polyhydroxyalkanoates." in: Biomaterials, Vol. 34, Issue 15, pp. 3737-46, 2013 (PubMed).

Li, Liu, Kan, Li, Liu, Lu: "Elevated expression of integrin αv and β5 subunit in laryngeal squamous-cell carcinoma associated with lymphatic metastasis and angiogenesis." in: Pathology, research and practice, Vol. 209, Issue 2, pp. 105-9, 2013 (PubMed).

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