MDC1 antibody (AA 31-130)
-
- Target See all MDC1 Antibodies
- MDC1 (Mdc1 (MDC1))
-
Binding Specificity
- AA 31-130
-
Reactivity
- Human, Mouse, Rat
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This MDC1 antibody is un-conjugated
-
Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Cross-Reactivity
- Human, Mouse, Rat
- Predicted Reactivity
- Dog,Cow,Pig,Horse
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human MDC1
- Isotype
- IgG
- Top Product
- Discover our top product MDC1 Primary Antibody
-
anti-Mdc1 (MDC1) antibody
MDC1 Reactivity: Human WB, IF, IHC (p), ICC Host: Rabbit Polyclonal unconjugated
anti-Mdc1 (MDC1) (AA 1-100) antibodyMDC1 Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Mdc1 (MDC1) (N-Term) antibodyMDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 unconjugated
anti-Mdc1 (MDC1) (N-Term) antibody (HRP)MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 HRP
anti-Mdc1 (MDC1) (N-Term) antibody (FITC)MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 FITC
anti-Mdc1 (MDC1) (N-Term) antibody (Alkaline Phosphatase (AP))MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 Alkaline Phosphatase (AP)
anti-Mdc1 (MDC1) (N-Term) antibody (Biotin)MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 Biotin
anti-Mdc1 (MDC1) (N-Term) antibody (PE)MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 PE
anti-Mdc1 (MDC1) (N-Term) antibody (PerCP)MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 PerCP
anti-Mdc1 (MDC1) (N-Term) antibody (APC)MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 APC
-
- Application Notes
-
WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
-
- Target
- MDC1 (Mdc1 (MDC1))
- Alternative Name
- MDC1 (MDC1 Products)
- Synonyms
- 6820401C03 antibody, AA413496 antibody, Nfbd1 antibody, mKIAA0170 antibody, NFBD1 antibody, mediator of DNA damage checkpoint 1 antibody, mediator of DNA-damage checkpoint 1 antibody, Mdc1 antibody, MDC1 antibody
- Background
-
Synonyms: NFBD1, Mediator of DNA damage checkpoint protein 1, Nuclear factor with BRCT domains 1, MDC1, KIAA0170
Background: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.
- Gene ID
- 9656
- UniProt
- Q14676
-
