Damage-Specific DNA Binding Protein 1, 127kDa (DDB1) antibody (Biotin)

Antigen: Damage-Specific DNA Binding Protein 1, 127kDa (DDB1)

Synonyms: XPE, DDBA, XAP1, XPCE, XPE-BF, UV-DDB1, DDB1, MGC143388, xpe, ddba, xap1, xpce, xpe-bf, uv-ddb1, DKFZp459H0524

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus), Horse (Equine), Cow (Bovine), Rabbit, Chicken

Conjugate: Biotin

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Flow Cytometry (FACS), Immunofluorescence (IF)

Catalog no.: ABIN742457

Additional Information

Alternative name: DDB1

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human DDB1 C-terminus

Format: Lyophilized

Reconstitution: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotype: IgG

Description: Synonym: DNA damage-binding protein 1, Damage specific DNA binding protein 1, DDB 1, DDB p127 subunit, DDBa, DNA damage binding protein 1, UV damaged DNA binding factor, UV damaged DNA binding protein 1, UV DDB 1, UV-DDB1, X associated protein 1, XAP 1, XAP1, Xeroderma pigmentosum group E complementing protein, XPCE, XPE, XPE binding factor, XPE-BF.

Molecular Weight: 125kDa

Comments:

This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However

it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition

Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q

but no sequence alternations of this gene are demonstrated in Best disease patients. [provided by RefSeq].

Application Details

Application Notes: WB (1:100-500), ELISA (1:500-1000), IP (1:20-100), IHC-P (1:100-500), IHC-F (1:100-500), Flow-Cyt (1:20-100), IF (1:50-200)

Concentration: 1mg/1ml

Purification: Antibodies are purified by protein A and peptide affinity chromatography.

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Storage: Ship at room temperature. Store at -20°C

Research Area: Chromatin and Nuclear Signaling, DNA/RNA

Restrictions: For Research Use only