Adenylate Cyclase 9 (ADCY9) antibody (PE)

Antigen: Adenylate Cyclase 9 (ADCY9)

Synonyms: AC9, ACtp10, AW125421, D16Wsu65e, mKIAA0520, adcy9, xlAC, ADCY9

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Rat (Rattus), Mouse (Murine)

Conjugate: PE

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Catalog no.: ABIN751253

Additional Information

Alternative name: ADCY9

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human ADCY9

Format: Lyophilized

Reconstitution: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotype: IgG

Description: Synonym: ADCY 9, Adenylate cyclase 9, Adenylate cyclase type 9, Adenylate cyclase type IX, Adenylyl cyclase 9, ATP pyrophosphate lyase 9, KIAA0520, Type IX adenylyl cyclase, Type IX ATP pyrophosphate lyase.

Specificity: Excitation / Emission Wavelengths: 565nm/578nm

Molecular Weight: 110kDa

Comments:

The membrane-bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein-coupled receptors (GPCRs). Using the high inter-species homology of mammalian AC isoforms

nine Adenylyl cyclase (AC) isoforms

encoded by separate genes

have been identified until today. Human adenylate cyclase genes comprise of 11 to 26 exons

which are distributed over 16 to 430kb. The expression profile of these 9 AC isoforms in a panel of 16 human tissues and in human embryonic kidney (HEK) cells have been demonstrated earlier. The cAMP synthesizing enzymes are found in two forms: cytosolic (soluble) and membrane-bound (particulate). Stimulation of adenylate cyclases produce cAMP form ATP in response to the activation of GPCRs by various hormones

neurotransmitters and other regulatory molecules. cAMP

in subsequent steps down the signal transduction pathway

can stimulate cAMP-dependent protein kinase A (cPKA)

and several other target molecules. Activation of cPKA can phosphorylate a broad range of substrates that regulate various metabolic pathways

gene expression

and affect memory functions etc. The stimulation of adenylate cyclases starts with interactions with GPCRs mediated signals initiated by Gs and Gi heterotrimeric G-proteins.

Application Details

Application Notes: Flow-Cyt (1:50-200), IF (1:50-200)

Concentration: 1mg/1ml

Purification: Antibodies are purified by protein A and peptide affinity chromatography.

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Storage: Ship at room temperature. Store at -20°C

Research Area: Cancer

Restrictions: For Research Use only