DDR2 antibody (Discoidin Domain Receptor tyrosine Kinase 2) (AA 275-320)

Details for Product anti-DDR2 Antibody No. ABIN755218, Supplier: Log in to see
Antigen
  • DDR2
  • ddr2
  • si:ch211-193c2.1
  • AW495251
  • Ntrkr3
  • tyro10
  • MIG20a
  • NTRKR3
  • TKT
  • TYRO10
  • Tyro10
  • discoidin domain receptor tyrosine kinase 2
  • discoidin domain receptor family, member 2b
  • discoidin domain receptor family, member 2
  • DDR2
  • ddr2b
  • LOC100356982
  • Ddr2
Alternatives
anti-Human DDR2 antibody for ELISA
Epitope
AA 275-320
15
13
12
11
8
6
4
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
90
34
4
1
1
Host
Rabbit
75
40
Clonality
Polyclonal
Conjugate
This DDR2 antibody is un-conjugated
4
4
4
4
4
4
2
2
2
2
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
84
58
38
22
17
12
5
3
2
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Immunogen KLH conjugated synthetic peptide derived from human CD167b/DDR2
Isotype IgG
Purification Purified by Protein A.
Alternative Name Cd167b (DDR2 Antibody Abstract)
Background

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

Subcellular location: Extracellular

Synonyms: TKT, MIG2a, NTRKR3, TYRO1, Discoidin domain-containing receptor 2, Discoidin domain receptor 2, CD167 antigen-like family member B, Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO1, CD167b, DDR2

Gene ID 4921
UniProt Q16832
Pathways RTK Signaling
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 275-320) antibody (ABIN755218) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-CD167B/DD...
Product cited in: Zhu, Gillespie, Jackson: "NPY1-36 and PYY1-36 activate cardiac fibroblasts: an effect enhanced by genetic hypertension and inhibition of dipeptidyl peptidase 4." in: American journal of physiology. Heart and circulatory physiology, Vol. 309, Issue 9, pp. H1528-42, 2015 (PubMed). Method employed by authors: Immunofluorescence (Cultured Cells) (IF (cc)) (Sample species: Rat (Rattus)).

Wang, Wang, Zhao, Li, Deng: "Angiotensin II upregulates K(Ca)3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts." in: Biochemical pharmacology, Vol. 85, Issue 10, pp. 1486-94, 2013 (PubMed).

Did you look for something else?