Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) antibody (Gold)

Antigen: Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1)

Synonyms: CEBP, CPEB, CPE-BP1, FLJ13203, MGC34136, MGC60106, Cpeb, mCPEB, AU024112, MGC159179, CPEB1, cpeb1, DKFZp459E225, Cpeb1, ZOR-1, fd15c06, MGC191213, wu:fd15c06

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Conjugate: Gold

Application: Immunoelectron Microscopy (IEM)

Catalog no.: ABIN761509

Additional Information

Alternative name: CPEB1

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human CPEB1

Format: Lyophilized

Reconstitution: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotype: IgG

Description: Synonym: CPE-binding protein 1, CPE-BP1, CPEB 1, CPEB, CPEB1, CPEB1 protein, CPEB1_HUMAN, Cytoplasmic polyadenylation binding protein 1, Cytoplasmic polyadenylation element binding protein, Cytoplasmic polyadenylation element binding protein 1, Cytoplasmic polyadenylation element-binding protein 1, h-CEBP, hCPEB-1.

Molecular Weight: 63kDa

Comments:

Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation

early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE)

an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA

a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites

those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.

Application Details

Application Notes: Electron Microscopy (1:100-500)

Concentration: 1mg/1ml

Purification: Antibodies are purified by protein A and peptide affinity chromatography.

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Storage: Ship at room temperature. Store at -20°C

Research Area: Neurology, DNA/RNA, Chromatin and Nuclear Signaling

Restrictions: For Research Use only