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LY75/DEC-205 antibody

LY75 Reactivity: Human WB, FACS, IHC (fro) Host: Mouse Monoclonal HD30 unconjugated
Catalog No. ABIN781804
  • Target See all LY75/DEC-205 (LY75) Antibodies
    LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))
    Reactivity
    • 42
    • 30
    • 6
    • 5
    • 2
    • 2
    Human
    Host
    • 40
    • 18
    • 6
    • 1
    • 1
    Mouse
    Clonality
    • 33
    • 32
    • 1
    Monoclonal
    Conjugate
    • 28
    • 9
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This LY75/DEC-205 antibody is un-conjugated
    Application
    • 23
    • 22
    • 20
    • 18
    • 14
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    This antibody recognizes CD205, an approx. 200 kDa C-type lectin transmembrane protein of the MMR (macrophage mannose receptor) family, expressed at high levels on dendritic cells and thymic epithelial cells, and at low levels on lymphocytes, NK cells and monocytes.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human
    Purification
    Protein-A affinity chromatography
    Purity
    > 95 % pure (by SDS-PAGE)
    Immunogen
    Recombinant Fc-tagged human CD205
    Clone
    HD30
    Isotype
    IgG1
    Top Product
    Discover our top product LY75 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
  • Target
    LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))
    Alternative Name
    CD205 / DEC-205 (LY75 Products)
    Synonyms
    LY75 antibody, MGC140308 antibody, DEC205 antibody, im:7150926 antibody, si:dkey-78p20.2 antibody, LYT75 antibody, CD205 antibody, DEC-205 antibody, CLEC13B antibody, GP200-MR6 antibody, LY-75 antibody, RGD1565962 antibody, Ly-75 antibody, lymphocyte antigen 75 antibody, CD205 protein antibody, CD302 antigen antibody, LY75 antibody, Cyan7822_2917 antibody, LY5 antibody, ly75 antibody, cd205 antibody, LOC100380704 antibody, LOC100433861 antibody, LOC100483541 antibody, Ly75 antibody
    Background
    CD205, also known as DEC-205, is an endocytic receptor of macrophage mannose receptor family. This 205 kDa C-type lectin transmembrane protein mediates adsorptive uptake and its intracellular domain contains coated pit localization sequence and distal acidic motif, which is required for recycling beyond early endosomes through deeper MHC II+ late endosomes and lysosomes. This unique pathway of receptor-mediated uptake proves to be necessary for presentation of antigenic peptides at low doses of ligand. CD205 is responsible for uptake and processing of captured antigens for dendritic cells.Synonyms: C-type lectin domain family 13 member B, CLEC13B, DEC205, LY75, Lymphocyte antigen 75, gp200-MR6
    Gene ID
    100526664
    NCBI Accession
    NP_001185688
    UniProt
    O60449
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