GSTA1 antibody (AA 1-222)

Catalog No. ABIN782405

Product Details anti-GSTA1 Antibody

Target: GSTA1 (Glutathione S-Transferase alpha 1 (GSTA1))

Binding Specificity: AA 1-222

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GSTA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to GSTA1.

Purification: Affinity chromatography on Protein A

Immunogen: GSTA1 antibody was raised against gSTA1 (AAH53578.1, 1 a.a. ~ 222 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 2F7

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0,5 mg/mL

Buffer: PBS, pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody at -20 °C to -80 °C.

Target Details for GSTA1

Target: GSTA1 (Glutathione S-Transferase alpha 1 (GSTA1))

Alternative Name: GSTA1 (GSTA1 Products)

Background: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.Synonyms: GST class-alpha member 1, GST-epsilon, GSTA1-1, GTH1, Glutathione S-transferase A1, HA subunit 1

Gene ID: 2938

NCBI Accession: NP_665683

UniProt: P08263