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Synaptojanin 1 antibody (C-Term)

SYNJ1 Reactivity: Rat WB, IHC (fro) Host: Mouse Monoclonal 5H1 unconjugated
Catalog No. ABIN782444
  • Target See all Synaptojanin 1 (SYNJ1) Antibodies
    Synaptojanin 1 (SYNJ1)
    Binding Specificity
    • 15
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 22
    • 17
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Rat
    Host
    • 31
    • 5
    Mouse
    Clonality
    • 32
    • 4
    Monoclonal
    Conjugate
    • 18
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Synaptojanin 1 antibody is un-conjugated
    Application
    • 17
    • 13
    • 13
    • 13
    • 5
    • 3
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    Specific for the ~145k Synaptojanin I protein in Western blots of Rat brain extracts. Immunolabeling blocked by preadsorption of antibody with the protein used to generate the antibody. Does not cross react with Mouse.
    Cross-Reactivity (Details)
    Species reactivity (tested):Rat.
    Purification
    Protein G Chromatography of Culture Supernatant.
    Immunogen
    Recombinant protein corresponding to amino acid residues from the C-terminal region of Rat Synaptojanin 1.
    Clone
    5H1
    Isotype
    IgG
    Top Product
    Discover our top product SYNJ1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody undiluted (in aliquots) at -20 °C.
  • Target
    Synaptojanin 1 (SYNJ1)
    Alternative Name
    Synaptojanin-1 / SYNJ1 (SYNJ1 Products)
    Synonyms
    CG6562 antibody, Dmel\\CG6562 antibody, IPP antibody, Synj antibody, fb02f11 antibody, fi15a11 antibody, nrc antibody, wu:fb02f11 antibody, wu:fi15a11 antibody, SYNJ1 antibody, INPP5G antibody, A930006D20Rik antibody, AA675315 antibody, mKIAA0910 antibody, Synaptojanin antibody, synaptojanin 1 antibody, Synj antibody, synj1 antibody, SYNJ1 antibody, Synj1 antibody
    Background
    Synaptojanin is a phosphatidylinositol phosphatase involved in clathrinmediated endocytosis of synaptic vesicles. Synaptojanin 1 has two alternatively spliced isoforms, one that is ~ 145 kDA and is exclusively expressed in neurons, and the other ~ 170 kDa which is expressed in non-neuronal, peripheral tissues (Ramjaun AR & McPherson PS, 1996). The gene which encodes Synaptojanin 1, SYNJ1, has been mapped to chromosome 21 thus making it a candidate for involvement in Down's syndrome (DS). It has recently been demonstrated that Ts65Dn mice (the most commonly used model of DS) have altered phosphatidyl-inositol-4,5-bisphosphate metabolism. This defect is rescued by restoring SYNJ1 to disomy in the Ts65Dn mice (Voronov SV et al., 2008).Synonyms: 4, 5-trisphosphate 5-phosphatase 1, INPP5G, KIAA0910, Synaptic Marker, Synaptic inositol-1
    Gene ID
    85238
    NCBI Accession
    NP_445928
    UniProt
    Q62910
    Pathways
    Inositol Metabolic Process, Synaptic Vesicle Exocytosis
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